Document Detail

Cardiorespiratory effects of desflurane in dogs given romifidine or medetomidine before induction of anesthesia with propofol.
MedLine Citation:
PMID:  17042386     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to evaluate the use of desflurane after induction of anesthesia with propofol in dogs sedated with romifidine or medetomidine. Each of 8 healthy dogs received intravenously, in random order, 3 preanesthetic protocols: romifidine, 40 microg/kg of body weight (BW) (R40); romifidine, 80 microg/kg BW (R80); and medetomidine, 10 microg/kg BW (MED). Cardiovascular and respiratory variables were recorded during the procedure. Time to extubation, time to sternal recumbency, and time to standing were also recorded. Heart rate and respiratory rate decreased significantly during sedation from baseline values, but there were no differences between the means for the 3 preanesthetic protocols. Mean values for heart rate, mean arterial blood pressure, systolic arterial pressure, diastolic arterial pressure, respiratory rate, tidal volume, arterial oxygen saturation, end-tidal CO2 level, pH, and arterial blood gas values during anesthesia were similar for the 3 protocols. The mean end-tidal desflurane concentration was significantly lower with the R80 protocol than with the R40 protocol. The mean time to extubation was significantly shorter with the R40 protocol than with the R80 and MED protocols.
Rafael J Gómez-Villamandos; José I Redondo; Eva M Martín; Juan M Domínguez; María M Granados; Indalecio Ruiz; José M Santisteban
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire     Volume:  70     ISSN:  0830-9000     ISO Abbreviation:  Can. J. Vet. Res.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-17     Completed Date:  2006-11-20     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  8607793     Medline TA:  Can J Vet Res     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  308-12     Citation Subset:  IM    
Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Campus Universitario de Rabanales, Córdoba, Spain.
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MeSH Terms
Anesthesia Recovery Period
Anesthetics / administration & dosage*
Blood Gas Analysis / veterinary
Blood Pressure / drug effects,  physiology
Cross-Over Studies
Dogs / physiology*
Dose-Response Relationship, Drug
Heart Rate / drug effects*,  physiology
Hypnotics and Sedatives / administration & dosage*
Imidazoles / administration & dosage
Isoflurane / analogs & derivatives*,  pharmacology
Medetomidine / administration & dosage
Oxygen Consumption
Propofol / administration & dosage
Respiration / drug effects*
Time Factors
Reg. No./Substance:
0/Anesthetics; 0/Hypnotics and Sedatives; 0/Imidazoles; 2078-54-8/Propofol; 26675-46-7/Isoflurane; 57041-67-5/desflurane; 65896-16-4/romifidine; 86347-14-0/Medetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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