Document Detail

Cardiorespiratory effects of changing inspiratory to expiratory ratio during high-frequency oscillation in an animal model of respiratory failure.
MedLine Citation:
PMID:  1495855     Owner:  NLM     Status:  MEDLINE    
To examine the effects of varying inspiratory/expiratory ratio (I/E) on cardiorespiratory function during high-frequency oscillation (HFO), 11 saline-lavaged rabbits were ventilated at I/E = 1:2, 1:1.5, 1.5:1, and 2:1 in a paired comparison to a baseline of I/E = 1:1. HFO was delivered by a SensorMedics model 3100 oscillator at a frequency of 10 Hz. Pressure amplitude and proximal mean airway pressure (PPaw) were held constant as I/E was varied from baseline to the experimental I/E. During each paired observation, PaO2, PaCO2, cardiac output, blood pressure, and distal mean airway pressure (DPaw) were measured. We found that as I/E was increased or decreased from 1:1, no significant changes in PaO2, PaCO2, blood pressure, or cardiac output occurred. We conclude that in this model, varying I/E has no significant effect on oxygenation, ventilation, or cardiovascular function.
S E Courtney; K R Weber; W A Spohn; C V Bender; S W Malin; R W Gotshall
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  13     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-09-10     Completed Date:  1992-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-6     Citation Subset:  IM    
Division of Newborn Medicine, Wright State University, Dayton, Ohio.
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MeSH Terms
Analysis of Variance
Blood Pressure*
Cardiac Output
Heart / physiopathology*
High-Frequency Ventilation*
Lung / physiopathology*
Lung Compliance
Respiratory Insufficiency / physiopathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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