Document Detail


Cardiorespiratory depression and plasma beta-endorphin levels in low-birth-weight infants during the first day of life.
MedLine Citation:
PMID:  2949599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-nine premature infants were studied to determine whether neonatal asphyxia, apnea, and low blood pressure in the first day of life are associated with elevated plasma beta-endorphin concentrations. Plasma beta-endorphin levels were determined at 0.5 to 2, 4 to 6, and 18 to 24 hours of life, using radioimmunoassay. Premature infants with moderate or severe asphyxia (n = 19) had higher levels at 0.5 to 2 hours of age (32.1 +/- 6.7 vs 16.4 +/- 7.4 pmol/L) and significantly higher levels at 4 to 6 hours of age (50.4 +/- 10.0 vs 22.9 +/- 9.2 pmol/L) compared with the ten nonasphyxiated premature infants. A significant elevation in levels at age 0.5 to 2 hours (39.4 +/- 9.9 vs 17.7 +/- 4.4 pmol/L) and age 4 to 6 hours (59.3 +/- 13.8 vs 27.1 +/- 17.1 pmol/L) was observed in premature infants with low blood pressure or impaired perfusion (n = 12) who required the administration of volume expanders. No differences were observed in premature infants with and without apnea. It may be speculated that the increased endogenous release of beta-endorphins in response to perinatal asphyxia may play a role in the pathogenesis of shock observed in the first day of life.
Authors:
S Davidson; I Gil-Ad; H Rogovin; Z Laron; S H Reisner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  141     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-02-27     Completed Date:  1987-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Apnea / blood*
Asphyxia Neonatorum / blood*
Endorphins / blood*
Humans
Hypotension / blood
Infant, Low Birth Weight / blood*
Infant, Newborn
Infant, Premature, Diseases / blood*
Radioimmunoassay
beta-Endorphin
Chemical
Reg. No./Substance:
0/Endorphins; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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