Document Detail

Cardiorespiratory depression and plasma beta-endorphin levels in low-birth-weight infants during the first day of life.
MedLine Citation:
PMID:  2949599     Owner:  NLM     Status:  MEDLINE    
Twenty-nine premature infants were studied to determine whether neonatal asphyxia, apnea, and low blood pressure in the first day of life are associated with elevated plasma beta-endorphin concentrations. Plasma beta-endorphin levels were determined at 0.5 to 2, 4 to 6, and 18 to 24 hours of life, using radioimmunoassay. Premature infants with moderate or severe asphyxia (n = 19) had higher levels at 0.5 to 2 hours of age (32.1 +/- 6.7 vs 16.4 +/- 7.4 pmol/L) and significantly higher levels at 4 to 6 hours of age (50.4 +/- 10.0 vs 22.9 +/- 9.2 pmol/L) compared with the ten nonasphyxiated premature infants. A significant elevation in levels at age 0.5 to 2 hours (39.4 +/- 9.9 vs 17.7 +/- 4.4 pmol/L) and age 4 to 6 hours (59.3 +/- 13.8 vs 27.1 +/- 17.1 pmol/L) was observed in premature infants with low blood pressure or impaired perfusion (n = 12) who required the administration of volume expanders. No differences were observed in premature infants with and without apnea. It may be speculated that the increased endogenous release of beta-endorphins in response to perinatal asphyxia may play a role in the pathogenesis of shock observed in the first day of life.
S Davidson; I Gil-Ad; H Rogovin; Z Laron; S H Reisner
Related Documents :
20401269 - Feeding premature infants after hospital discharge.
21947019 - Stridor at birth predicts poor outcome in neonates with myelomeningocele.
10591429 - Passive immunity of premature infants against measles during early infancy.
24367569 - Lipsmacking imitation skill in newborn macaques is predictive of social partner discrim...
10711549 - Interpregnancy interval and the risk of premature infants.
576399 - Retrolental fibroplasia: i. clinical observations.
2748359 - New fathers' blood pressure and heart rate: relationships to interaction with their new...
2916609 - Association of episiotomy and delivery position with deep perineal laceration during sp...
21304419 - Herpes simplex virus infection in young infants during 2 decades of empiric acyclovir t...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  141     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-02-27     Completed Date:  1987-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apnea / blood*
Asphyxia Neonatorum / blood*
Endorphins / blood*
Hypotension / blood
Infant, Low Birth Weight / blood*
Infant, Newborn
Infant, Premature, Diseases / blood*
Reg. No./Substance:
0/Endorphins; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The reaction of skin to primers used in the "single-step" bonding systems.
Next Document:  Alterations in helper-specific circulating T lymphocytes and in the autologous mixed lymphocyte reac...