Document Detail


Cardiorespiratory alterations induced by intermittent hypoxia in a rat model of sleep apnea.
MedLine Citation:
PMID:  20217364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The obstructive sleep apnea (OSA) syndrome, characterized by repeated episodes of intermittent hypoxia is recognized as an independent risk factor for hypertension. One potential contributing mechanism to the OSA-induced hypertension is the potentiation of the carotid body chemosensory responses to hypoxia, which is responsible for the augmented sympathetic modulation of heart rate variability (HRV) and the enhanced ventilatory response to hypoxia found in OSA patients and animal exposed to chronic intermittent hypoxia (CIH). However, it is not known if the cardiorespiratory alterations may precede the hypertension. Thus, we studied the effects of CIH on arterial pressure, HRV and ventilatory response to acute hypoxia in rats exposed to CIH (5% O(2), 12 times/h per 8 h) or sham condition for 7-21 days. Exposure of rats to CIH for 14 days enhanced the ventilatory response to hypoxia and produced a significant shift of the HRV power spectrum, with a predominance of the sympathetic modulation. These cardiorespiratory alterations occurred without noticeable changes in arterial blood pressure, until 21 days of CIH exposure. Thus, our results support the idea that the hypertension induced by CIH was preceded by alterations in the autonomic balance of HRV, associated with an enhance chemoreflex ventilatory reactivity in normotensive animals.
Authors:
Rodrigo Iturriaga; Esteban A Moya; Rodrigo Del Rio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  669     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Affiliation:
Laboratorio de Neurobiolog?a, P. Universidad Cat?lica de Chile, Santiago, Chile. riturriaga@bio.puc.cl
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / complications*,  physiopathology*
Blood Pressure
Cardiovascular System / physiopathology*
Disease Models, Animal
Heart Rate
Male
Pulmonary Ventilation
Rats
Rats, Sprague-Dawley
Reflex
Respiratory System / physiopathology*
Sleep Apnea Syndromes / complications*,  physiopathology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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