Document Detail


Cardiorespiratory adaptations to exercise in cystic fibrosis.
MedLine Citation:
PMID:  7103246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared the cardiorespiratory adaptations to exercise of 21 patients with cystic fibrosis (CF) with those of 17 age-, height-, and weight-matched subjects without lung disease. To assess differences in adaptations to exercise in patients with varying severities of pulmonary disease, we grouped them on the basis of their lung function tests results. Exercise consisted of a progressive, incremental cycle ergometer work test. Work load increased every 2 min until the subject could not continue. During exercise, heart rate, and end-tidal and mixed expired O2 and CO2 tensions, minute ventilation (VE), arterial oxygen saturation, and blood pressure were monitored. The patients breathed significantly larger volumes than normal subjects at work loads greater than 0.8 W/kg. Patients with mild, moderate, or seven disease ventilated more per unit of oxygen consumption than did patients with normal pulmonary functions or control subjects. Despite this high total VE, alveolar hypoventilation was observed in the severe groups, as evidenced by elevated end-tidal PCO2, and contributed to aterial desaturation. Resting heart rate was higher in the severe group. The rate of changes in heart rate with increasing work load was the same in all groups. We conclude that the increased VE during exercise was an attempt to maintain alveolar ventilation in the face of increased dead space. The elevated VE was adequate to preserve normal gas exchange in all patients except those with severe lung disease, where CO2 retention and arterial desaturation were observed.
Authors:
F J Cerny; T P Pullano; G J Cropp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  126     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Cystic Fibrosis / physiopathology*
Female
Hemodynamics*
Humans
Male
Oxygen / physiology
Physical Exertion*
Pulmonary Alveoli / physiopathology
Respiration*
Respiratory Function Tests
Grant Support
ID/Acronym/Agency:
1 RO1 AM24006-01/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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