Document Detail

Cardiorespiratory fitness, waist circumference, and alanine aminotransferase in youth.
MedLine Citation:
PMID:  23190589     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Nonalcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome and is strongly associated with cardiometabolic diseases. In adults, cardiorespiratory fitness (CRF) is inversely associated with alanine aminotransferase (ALT), a blood biomarker for NAFLD. However, information regarding these associations is scarce for youth. The objective of this study is to examine associations between CRF, waist circumference, and ALT in youth.
METHODS: Data were obtained from youth (n = 2844, 12-19 yr) in the National Health and Nutrition Examination Survey 2001-2004. CRF was dichotomized into youth FITNESSGRAM categories of "low" and "adequate" CRF. Logistic and quantile regression were used for a comprehensive analysis of associations, and variables with previously reported associations with ALT were a priori included in the models.
RESULTS: Results from logistic regression suggested that youth with low CRF had 1.5 times the odds of having an ALT >30 than youth with adequate CRF, although the association was not statistically significant (P = 0.09). However, quantile regression demonstrated that youth with low CRF had statistically significantly higher ALT (+1.04, +1.05, and +2.57 U·L) at the upper end of the ALT distribution (80th, 85th, and 90th percentiles, respectively) than youth with adequate CRF. For every 1-cm increase in waist circumference, the odds of having an ALT >30 increased by 1.06 (P < 0.001), and the strength of this association increased across the ALT distribution.
CONCLUSIONS: Future studies should examine whether interventions to improve CRF can decrease hepatic fat and liver enzyme concentrations in youth with ALT ≥80th percentile or in youth diagnosed with NAFLD.
Jennifer L Trilk; Andrew Ortaglia; Steven N Blair; Matteo Bottai; Timothy S Church; Russell R Pate
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-11-14     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  722-7     Citation Subset:  IM; S    
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MeSH Terms
Alanine Transaminase / blood*
Cardiovascular System*
Fatty Liver / blood*
Logistic Models
Nutrition Surveys
Physical Fitness / physiology*
Respiratory System*
United States
Waist Circumference*
Young Adult
Grant Support
Reg. No./Substance:
EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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