| Cardiorespiratory fitness is independently associated with 25-hydroxyvitamin D in chronic kidney disease. | |
| | |
MedLine Citation:
|
PMID: 21164020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVES: Vitamin D is an established important contributor to muscle function and aerobic metabolism. Hypovitaminosis D is highly prevalent in CKD patients and is associated with increased cardiovascular (CV) mortality via unknown mechanisms. Because aerobic-exercise capacity strongly predicts future CV events, we hypothesized that vitamin D status could be linked to CV outcomes via an effect on maximum aerobic-exercise capacity in patients with CKD and that this effect may be mediated in part via its actions on muscle strength and functional ability. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Baseline demographic, anthropometric, and biochemical data were collected in a cross-sectional study of patients with moderate CKD. Peak aerobic capacity was determined during treadmill stress testing using metabolic equivalence of tasks. Physical activity was assessed using the Active Australia questionnaire, grip strength by dynamometer, and functional capacity by "Up & Go" testing. RESULTS: The study included 85 participants (age 59.5 ± 9.7 years, 60% male, 44% diabetic, 92% Caucasian; mean serum 25-hydroxyvitamin D [25-OHD] 78.4 ± 29.4 nmol/L). We demonstrated that 25-OHD status was independently associated with aerobic-exercise capacity (β = 0.2; P = 0.008). Aerobic-exercise capacity was also predicted by younger age, white race, smaller waist circumference, absence of a previous angina history, and increasing weekly physical activity. However, neither muscle strength nor functional ability were significantly associated with 25-OHD. CONCLUSIONS: Vitamin D is independently associated with aerobic capacity in CKD patients, and this finding is not explained by changes in muscle strength or functional ability. |
| | |
Authors:
|
William G Petchey; Erin J Howden; David W Johnson; Carmel M Hawley; Thomas Marwick; Nicole M Isbel |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-12-16 |
Journal Detail:
|
Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 6 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-17 Completed Date: 2011-06-30 Revised Date: 2012-03-01 |
Medline Journal Info:
|
Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
|
Languages: eng Pagination: 512-8 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. william_petchey@health.qld.gov.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Analysis of Variance Biological Markers / blood Cardiovascular Diseases / blood, etiology*, physiopathology Chronic Disease Cross-Sectional Studies Exercise Test Exercise Tolerance Female Hand Strength Humans Kidney Diseases / blood, complications*, physiopathology Linear Models Male Middle Aged Muscle Strength Muscle Strength Dynamometer Physical Fitness* Queensland Questionnaires Randomized Controlled Trials as Topic Vitamin D / analogs & derivatives*, blood Vitamin D Deficiency / blood, complications*, physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sclerostin and Dickkopf-1 in renal osteodystrophy.
Next Document: The regulation of parathyroid hormone secretion and synthesis.