| Cardioreparation and the concept of modulating cardiovascular structure and function. | |
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MedLine Citation:
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PMID: 8193734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension and atherosclerotic cardiovascular disease represent major global health problems. Practising physicians are challenged daily by patients suffering adverse cardiovascular events, such as myocardial infarction, stroke, heart failure and sudden cardiac death. Major risk factors have been identified of which the most important is left ventricular hypertrophy. In recent years, growth factors, regulatory peptides and effector hormones of the renin-angiotensin-aldosterone system have been identified as important modulators of cell growth and behaviour. It therefore follows that a major emphasis has been placed on the importance of abnormalities in organ structure as the primary basis for impaired function of the heart and vasculature, including large and medium sized arteries and resistance vessels, or arterioles. The concept of reparation recognizes the importance of abnormalities in tissue structure to the functional basis of disease. It suggests that the structurally remodelled heart and vasculature can be restored to, or toward, normal structure and function by suitable therapy. Experimental and clinical trials which address this premise are reviewed herein. |
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Authors:
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K T Weber; C G Brilla; J G Cleland; J N Cohn; L Hansson; A M Heagerty; J H Laragh; S Laurent; J P Ollivier; P Pauletto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Blood pressure Volume: 2 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1994-06-30 Completed Date: 1994-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: NORWAY |
Other Details:
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Languages: eng Pagination: 6-21 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Missouri-Columbia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / pathology, physiopathology*, therapy Heart / physiopathology* Humans Hypertension / physiopathology Myocardium / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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