Document Detail


Cardiorenal Syndrome: Pathophysiology, Preclinical Models, Management and Potential Role of Uraemic Toxins.
MedLine Citation:
PMID:  22014026     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
1. Cardiorenal syndrome (CRS) describes the primary dysfunction in either the kidney or heart that initiates the combined impairments of both organs. The heart and the kidney exert reciprocal control of the respective function to maintain constant blood volume and organ perfusion under continuously changing conditions. 2. The pathophysiology of CRS is not fully understood, but appears to be caused by a complex combination of hemodynamic, neurohormonal, immunological and biochemical feedback pathways. Amongst these pathways, the contributory role of uraemic toxins that accumulate in CRS has been under-explored. One such toxin, indoxyl sulfate, has been found to have direct adverse effects on relevant cardiac cells. 3. Early diagnosis by assessing cardiac and renal injury biomarkers may be critical for timely therapeutic intervention. Such therapies are directed at attenuation of neurohormonal activation, control of elevated blood pressure, correction of anaemia and relief of hypervolaemia. Reduction of non-dialyzable uraemic toxins is a further potentially beneficial therapeutic strategy.
Authors:
Shan Liu; Suree Lekawanvijit; Andrew R Kompa; Bing H Wang; Darren J Kelly; Henry Krum
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-20
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.
Affiliation:
Centre for Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia. Departments of Medicine, University of Melbourne, St. Vincent's Hospital, Vic, Australia.
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