| Cardiorenal syndrome: diagnosis, treatment, and clinical outcomes. | |
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MedLine Citation:
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PMID: 20737257 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The pathophysiologic interactions that link the heart and kidney are multiple and complex, and have been grouped under the umbrella term "cardiorenal syndrome." In the setting of acute decompensated heart failure, worsening renal function has been directly associated with poor clinical prognosis and complicates treatment. However, the pathophysiology underlying acute cardiorenal syndrome remains incompletely understood and treatment options remain limited. Traditionally, the development of worsening renal function in acute decompensated heart failure has been attributed to renal arterial underfilling due to reduced cardiac output or intravascular volume depletion. However, increasing data have expanded our understanding of the roles that venous congestion and intra-abdominal pressure play in driving renal injury, with important implications for therapeutic management and the development of novel renal-sparing therapies. |
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Authors:
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Kevin Shrestha; W H Wilson Tang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current heart failure reports Volume: 7 ISSN: 1546-9549 ISO Abbreviation: Curr Heart Fail Rep Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101196487 Medline TA: Curr Heart Fail Rep Country: United States |
Other Details:
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Languages: eng Pagination: 167-74 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3-4, Cleveland, OH 44195, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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