Document Detail

Cardiopulmonary responses to intravenous infusion of soluble and relatively insoluble gases.
MedLine Citation:
PMID:  9094273     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Carbon dioxide is the current gas of choice for pneumoperitoneum, but hemodynamic and acid-base effects secondary to its systemic absorption have been reported. Various studies have suggested inert gases as alternatives. METHODS: We studied the cardiopulmonary responses to intravenous infusion of carbon dioxide, nitrous oxide, argon, helium, and nitrogen in anesthetized swine. The gas was infused into the femoral vein at a rate of 0.1 ml . kg-1 . min-1 for 30 min. The changes in end-tidal CO2, mean arterial pressure, hemodynamics, and arterial blood gases were compared to baseline values. RESULTS: No animals died during infusion of the soluble gases (CO2 and N2O). Three of the five pigs infused with nitrogen died suddenly at 20 and 30 min of infusion. The animals in the insoluble gas groups (Ar, He, N2) experienced clinical pulmonary gas embolism and severe acidemia, hypercapnea and tachycardia. CONCLUSIONS: Venous gas embolism is poorly tolerated when the gas is relatively insoluble. Insoluble gases should not be used for pneumoperitoneum when there is any risk of venous gas embolism.
M W Roberts; K A Mathiesen; H S Ho; B M Wolfe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgical endoscopy     Volume:  11     ISSN:  0930-2794     ISO Abbreviation:  Surg Endosc     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-23     Completed Date:  1997-06-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  341-6     Citation Subset:  IM; S    
Department of Surgery, University of California Davis Medical Center, 4301 X Street, Room 2310, Sacramento, CA 95817, USA.
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MeSH Terms
Argon / administration & dosage,  pharmacology
Carbon Dioxide / administration & dosage,  pharmacology
Embolism, Air / etiology*
Gases / administration & dosage,  pharmacology*
Helium / administration & dosage,  pharmacology
Hemodynamics / drug effects
Infusions, Intravenous
Nitrogen / administration & dosage,  pharmacology
Nitrous Oxide / administration & dosage,  pharmacology
Pneumoperitoneum, Artificial* / adverse effects
Pulmonary Embolism / etiology*
Risk Factors
Reg. No./Substance:
0/Gases; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 7440-37-1/Argon; 7440-59-7/Helium; 7727-37-9/Nitrogen

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