Document Detail


Cardiopulmonary responses to continuous administration of endotoxin.
MedLine Citation:
PMID:  3364588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiopulmonary response to continuous administration of lipopolysaccharide (LPS) was studied in chronically instrumented sheep. LPS was administered in doses of 0 (sham), 6, 9, 12, and 24 ng.kg-1.h-1 for 24 h. No significant changes in the measured variables occurred in the sham group and in the 6 ng.kg-1.h-1-LPS group. With 9, 12, and 24 ng.kg-1.h-1-LPS, cardiac index rose and peripheral resistance fell to the same extent in all three groups. Lung lymph flow (QL) increased with increasing concentration of LPS. These elevations in QL occurred in the presence of only minor increases in the pulmonary artery pressure, which rose to the same extent in the 9, 12, and 24 ng.kg-1.h-1 groups. Consequently, the changes in QL were attributable to changes in fluid conductance of the pulmonary microvasculature rather than variations in hydrostatic pressure. The increase in QL correlated with a decrease in prekallikrein levels (r = 0.97), indicating that the changes in fluid conductance might have been kinin mediated.
Authors:
D L Traber; H Redl; G Schlag; D N Herndon; R Kimura; T Prien; L D Traber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  254     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H833-9     Citation Subset:  IM    
Affiliation:
Ludwig Boltzmann Institute of Traumatology, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cardiac Output / drug effects
Female
Heart / drug effects*
Hemodynamics / drug effects
Leukocyte Count
Lipopolysaccharides / pharmacology*
Lung / drug effects*
Lymphatic System / drug effects
Prekallikrein / metabolism
Sheep
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
HL-34752/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 9055-02-1/Prekallikrein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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