Document Detail

Cardiopulmonary reflex impairment in experimental diabetes in rats.
MedLine Citation:
PMID:  10523366     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to evaluate the sensitivity of the cardiopulmonary receptors in experimental diabetes induced by streptozotocin by the use of 2 different methods: (1) administration of increasing doses of serotonin to analyze peak changes of arterial pressure and heart rate for each given dose in conscious intact normal and diabetic rats; (2) expanding blood volume with the use of dextran (6%) to produce similar increases in left ventricular end-diastolic pressure to quantify the arterial pressure, heart rate, and renal sympathetic nerve activity in sinoaortic, denervated, anesthetized normal and diabetic rats. Blood samples were collected to measure blood glucose. Diabetic rats showed hyperglycemia (22+/-0. 7 versus 7+/-0.2 mmol/L), reduced body weight (226+/-12 versus 260+/-4 g) and heart rate (294+/-14 versus 350+/-10 bpm), and similar arterial pressure (104+/-4 versus 113+/-4 mm Hg) when compared with control rats. Serotonin induced significant bradycardia and hypotension, which were similar and proportional to the dose injected in both groups. Mean arterial pressure and heart rate decreases in response to volume overload were significantly lower in diabetic than in control rats. The reflex reduction of the renal sympathetic nerve activity as expressed by percentage changes in nerve activity in response to increasing left end-diastolic pressure was abolished in diabetic animals (1.9+/-0.8% versus -14+/-4%/mm Hg in controls). These results showed an impairment of cardiopulmonary reflex control of circulation in diabetes during acute volume expansion. The normal responses to serotonin administration indicated that the cardiopulmonary reflex is still preserved in diabetic rats.
V L Oliveira; E D Moreira; V D Farah; F Consolim-Colombo; E M Krieger; M C Irigoyen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  34     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-09     Completed Date:  1999-11-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  813-7     Citation Subset:  IM    
Experimental Division and Hypertension Unit, Heart Institute, University of São Paulo, Brazil.
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MeSH Terms
Blood Volume
Dextrans / pharmacology
Diabetes Mellitus, Experimental / physiopathology*
Free Radical Scavengers / pharmacology
Heart / innervation,  physiology
Lung / innervation,  physiology
Plasma Substitutes / pharmacology
Rats, Wistar
Serotonin / pharmacology
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:
0/Free Radical Scavengers; 0/Plasma Substitutes; 50-67-9/Serotonin; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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