Document Detail

Cardiopulmonary impairment in young women with polycystic ovary syndrome.
MedLine Citation:
PMID:  16757529     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Insulin resistance is a feature of polycystic ovary syndrome (PCOS), and it is related to mitochondrial function, particularly with maximal oxygen consumption (VO(2max)). At the moment, no evaluation of cardiopulmonary functional capacity in young patients with PCOS has been performed. OBJECTIVE: Our objective was to assess cardiopulmonary functional capacity in young PCOS overweight patients. DESIGN AND SETTING: We conducted a prospective baseline-controlled clinical study at University Federico II of Naples, School of Medicine (Naples, Italy). PATIENTS: Forty-five PCOS patients were matched with 45 healthy women for age (mean +/- sd, 21.3 +/- 2.0 vs. 21.6 +/- 1.9 yr, respectively) and body mass index (29.4 +/- 3.6 vs. 29.0 +/- 3.4 kg/m(2), respectively). MEAN OUTCOME MEASURES: We assessed hormonal and metabolic pattern and functional capacity by cardiopulmonary exercise testing to evaluate maximal oxygen consumption (VO(2max)), oxygen consumption at anaerobic threshold (VO(2AT)), and the maximal workload at peak exercise. RESULTS: VO(2max) (17.0 +/- 3.7 vs. 26.8 +/- 3.5 ml/kg.min), oxygen consumption at anaerobic threshold (13.9 +/- 3.0 vs. 21.2 +/- 3.8 ml/kg.min), and maximal workload at peak exercise (101.3 +/- 25.2 vs. 135 +/- 22.6 W) were significantly (P < 0.001) reduced in PCOS subjects compared with healthy women. The multiple linear regression analysis showed that only homeostasis model assessment appears to have a strong negative linear relation with VO(2max) in PCOS. No relation was found in controls. CONCLUSIONS: Our data demonstrate a reduced cardiopulmonary functional capacity in young PCOS patients.
Francesco Orio; Francesco Giallauria; Stefano Palomba; Teresa Cascella; Francesco Manguso; Laura Vuolo; Tiziana Russo; Achille Tolino; Gaetano Lombardi; Annamaria Colao; Carlo Vigorito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-06
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  91     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-08     Completed Date:  2006-09-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2967-71     Citation Subset:  AIM; IM    
Department of Molecular, Clinical Endocrinology, and Oncology, University Federico II of Naples, Via S. Pansini 5, 80131 Naples, Italy.
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MeSH Terms
Anaerobic Threshold
Blood Glucose / analysis
Body Mass Index
C-Reactive Protein / analysis
Exercise Test
Heart / physiopathology*
Insulin / blood
Insulin Resistance
Linear Models
Lung / physiopathology*
Oxygen Consumption
Physical Exertion
Polycystic Ovary Syndrome / physiopathology*
Prospective Studies
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 9007-41-4/C-Reactive Protein

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