Document Detail

Cardiopulmonary function during 7 h of constant-dose halothane and methoxyflurane.
MedLine Citation:
PMID:  3693168     Owner:  NLM     Status:  MEDLINE    
Cardiopulmonary effects of prolonged, constant-alveolar-dose halothane (HAL) and methoxyflurane (MOF) in O2 anesthesia on spontaneously breathing dogs were determined. One hour after anesthetic induction, end-tidal concentration was set at 1.04% HAL or 0.28% MOF [each representing 1.2 minimum alveolar concentration (MAC) for dogs] and maintained for 7 h. No time-related changes were associated with MOF. However, HAL significantly (P less than 0.05) elevated cardiac output (Q) from 2 to 7 h by increasing stroke volume; mean aortic pressure (MAP) also increased with time (P less than 0.05 beginning at 5 h). Four of these dogs were studied again at least 3 wk later at a constant end-tidal dose of 1.48% HAL in O2 (1.7 MAC). Q and MAP were lower initially during 1.7 MAC than during 1.2 MAC but not after 2 h of anesthesia. The greater HAL dose initially depressed ventilation and elevated arterial partial pressure of CO2 (PaCO2) compared with the lower dose. PaCO2 continued to increase with duration of 1.7 MAC HAL, as did results of ventilatory gas volume and flow measurements.
E P Steffey; T B Farver; M J Woliner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  63     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-12     Completed Date:  1988-02-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1351-9     Citation Subset:  IM    
Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616.
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MeSH Terms
Halothane / pharmacology*
Hemodynamics / drug effects*
Methoxyflurane / pharmacology*
Respiration / drug effects*
Time Factors
Reg. No./Substance:
151-67-7/Halothane; 76-38-0/Methoxyflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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