| Cardiopulmonary function during 7 h of constant-dose halothane and methoxyflurane. | |
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MedLine Citation:
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PMID: 3693168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiopulmonary effects of prolonged, constant-alveolar-dose halothane (HAL) and methoxyflurane (MOF) in O2 anesthesia on spontaneously breathing dogs were determined. One hour after anesthetic induction, end-tidal concentration was set at 1.04% HAL or 0.28% MOF [each representing 1.2 minimum alveolar concentration (MAC) for dogs] and maintained for 7 h. No time-related changes were associated with MOF. However, HAL significantly (P less than 0.05) elevated cardiac output (Q) from 2 to 7 h by increasing stroke volume; mean aortic pressure (MAP) also increased with time (P less than 0.05 beginning at 5 h). Four of these dogs were studied again at least 3 wk later at a constant end-tidal dose of 1.48% HAL in O2 (1.7 MAC). Q and MAP were lower initially during 1.7 MAC than during 1.2 MAC but not after 2 h of anesthesia. The greater HAL dose initially depressed ventilation and elevated arterial partial pressure of CO2 (PaCO2) compared with the lower dose. PaCO2 continued to increase with duration of 1.7 MAC HAL, as did results of ventilatory gas volume and flow measurements. |
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Authors:
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E P Steffey; T B Farver; M J Woliner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 63 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1988-02-12 Completed Date: 1988-02-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1351-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Female Halothane / pharmacology* Hemodynamics / drug effects* Male Methoxyflurane / pharmacology* Respiration / drug effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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151-67-7/Halothane; 76-38-0/Methoxyflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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