Document Detail

Cardiopulmonary exercise testing: a review of methods and applications in surgical patients.
MedLine Citation:
PMID:  20689441     Owner:  NLM     Status:  MEDLINE    
Cardiopulmonary exercise (CPX) testing has a number of medical applications, including the assessment of heart failure and the investigation of unexplained breathlessness. Over the past decade, it has become an important preoperative assessment tool to evaluate functional capacity and predict outcomes in patients undergoing both cardiac and noncardiac surgery. A CPX test is an incremental exercise test during which respiratory variables, including oxygen uptake and carbon dioxide excretion are measured and the ECG is monitored. Among the variables reported from a CPX test are oxygen uptake at anaerobic threshold and peak oxygen uptake. A limited functional capacity as indicated by a low anaerobic threshold or VO(2peak) has been shown to be associated with an increased incidence of perioperative complications in a number of surgical settings. Other reported variables, including the ventilatory equivalents for oxygen (VE/VO(2)) and carbon dioxide (VE/VCO(2)) and the millilitre of oxygen delivered per heartbeat or oxygen pulse [VO(2)/heart rate (HR)] may give indications as to the reasons for exercise limitation. ECG evidence of myocardial ischaemia with increasing workload is also an important indicator of increased perioperative risk. As a noninvasive, low-risk, test of the integrated responses to increasing cardiovascular stress, anaesthesiologists involved in preoperative assessment should have an understanding of its current uses and test outcomes. This review presents the physiological basis for CPX testing, methodology, advantages over other preoperative tests of cardiovascular function and guidance on the interpretation of CPX results in the perioperative setting.
Zoe A Ridgway; Simon J Howell
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  27     ISSN:  1365-2346     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  858-65     Citation Subset:  IM    
Department for Attribution, Leeds Institute of Molecular Medicine, University of Leeds, UK.
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MeSH Terms
Anaerobic Threshold
Carbon Dioxide / metabolism
Cardiovascular Diseases / diagnosis*,  physiopathology
Exercise Test / methods*
Oxygen / metabolism
Preoperative Care / methods*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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