Document Detail

Cardiopulmonary exercise testing in obstructive sleep apnea syndrome.
MedLine Citation:
PMID:  16448931     Owner:  NLM     Status:  MEDLINE    
To investigate whether cardiac dysfunction or abnormal measurements on cardiopulmonary exercise testing (CPET) are present in patients with obstructive sleep apnea syndrome (OSAS) and what factors are responsible for exercise limitation in these patients. We enrolled 20 patients with moderate or severe OSAS in the OSA group and 20 subjects without OSAS in the control group. All subjects underwent a sleep study and cardiac evaluation by radionuclide scanning and CPET. There was no difference in left ventricular ejection fraction (VEF) between the two groups, but the OSA group had a lower right VEF. Patients in the OSA group had a lower VO2(peak), VO2(peak/kg) and workpeak than the control group. The OSA group had a higher breathing reserve and a greater decrease in anaerobic threshold (AT) and oxygen pulse. In conclusion, patients with moderate to severe OSAS had abnormal CPET results. These abnormalities may be due to cardiac disease, pulmonary vascular disease, or possible lack of fitness.
Ching-Chi Lin; Wen-Yeh Hsieh; Chon-Shin Chou; Shwu-Fang Liaw
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  150     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  27-34     Citation Subset:  IM    
Chest Division, Department of Internal Medicine, Department of Medical Research, Mackay Memorial Hospital, 92, Sec 2, Chung Shan North Road, Taipei, Taiwan.
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MeSH Terms
Continuous Positive Airway Pressure / methods*
Exercise Test*
Middle Aged
Polysomnography / methods
Respiratory Function Tests / methods
Sleep / physiology
Sleep Apnea, Obstructive / physiopathology*

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