Document Detail

Cardiopulmonary exercise testing in heart transplant candidates.
MedLine Citation:
PMID:  11056772     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: We evaluated the results of patients with congestive heart failure (CHF) who underwent cardiopulmonary exercise testing (CPET) as part of their assessment for heart transplantation in order to examine the relationship between exercise capacity and resting indices of left ventricular function in these patients. MATERIALS AND METHODS: Twenty-seven ambulatory heart transplant candidates underwent CPET using a cycle ergometer and an incremental work-rate protocol till symptom-limitation. These patients included 24 men and 3 women with a mean age of 42.3 years. The aetiology of CHF was coronary artery disease in 14 patients, dilated cardiomyopathy in 11 patients, and congenital heart disease in 2 patients. Mean resting left ventricular ejection fraction (LVEF) was 19% (range 7% to 36%). RESULTS: Thirteen of the 27 tests performed were maximal studies and all except 2 subjects attained a measurable anaerobic threshold during CPET. Of the 13 maximal tests, the causes of exercise limitation were cardiomyopathy in 3 patients, ischaemic heart disease in 2 patients, significant oxygen desaturation in 2 patients, ventilatory limitation due to obstructive lung disease in 1 patient, ventilatory limitation secondary to a restrictive lung disease in 3 patients, and combined obstructive ventilatory and cardiovascular limitation in 2 patients. There was no significant correlation between resting LVEF and peak VO2 percent predicted (r = 0.14, P = 0.49). CONCLUSIONS: Exercise intolerance in patients with CHF may not be related to limited cardiac reserve and non-cardiac causes of exertional symptoms should also be considered. CPET is useful for the evaluation of functional capacity and mechanisms of exercise intolerance in patients with CHF.
K C Ong; J P Benedicto; A H Chan; Y S Tan; Y Y Ong
Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  29     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2001-01-31     Completed Date:  2001-02-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  442-6     Citation Subset:  IM    
Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Exercise Test* / instrumentation,  methods
Exercise Tolerance
Heart Failure / diagnosis*,  etiology,  physiopathology,  surgery*
Heart Transplantation*
Middle Aged
Patient Selection*
Preoperative Care*
Respiratory Function Tests* / instrumentation,  methods
Stroke Volume
Ventricular Function, Left
Waiting Lists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Use of low molecular weight heparin for prevention of deep vein thrombosis in total knee arthroplast...
Next Document:  Prophylactic esmolol infusion for the control of cardiovascular responses to extubation after intrac...