| Cardiopulmonary exercise testing in heart transplant candidates. | |
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MedLine Citation:
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PMID: 11056772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: We evaluated the results of patients with congestive heart failure (CHF) who underwent cardiopulmonary exercise testing (CPET) as part of their assessment for heart transplantation in order to examine the relationship between exercise capacity and resting indices of left ventricular function in these patients. MATERIALS AND METHODS: Twenty-seven ambulatory heart transplant candidates underwent CPET using a cycle ergometer and an incremental work-rate protocol till symptom-limitation. These patients included 24 men and 3 women with a mean age of 42.3 years. The aetiology of CHF was coronary artery disease in 14 patients, dilated cardiomyopathy in 11 patients, and congenital heart disease in 2 patients. Mean resting left ventricular ejection fraction (LVEF) was 19% (range 7% to 36%). RESULTS: Thirteen of the 27 tests performed were maximal studies and all except 2 subjects attained a measurable anaerobic threshold during CPET. Of the 13 maximal tests, the causes of exercise limitation were cardiomyopathy in 3 patients, ischaemic heart disease in 2 patients, significant oxygen desaturation in 2 patients, ventilatory limitation due to obstructive lung disease in 1 patient, ventilatory limitation secondary to a restrictive lung disease in 3 patients, and combined obstructive ventilatory and cardiovascular limitation in 2 patients. There was no significant correlation between resting LVEF and peak VO2 percent predicted (r = 0.14, P = 0.49). CONCLUSIONS: Exercise intolerance in patients with CHF may not be related to limited cardiac reserve and non-cardiac causes of exertional symptoms should also be considered. CPET is useful for the evaluation of functional capacity and mechanisms of exercise intolerance in patients with CHF. |
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Authors:
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K C Ong; J P Benedicto; A H Chan; Y S Tan; Y Y Ong |
Publication Detail:
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Type: Journal Article; Validation Studies |
Journal Detail:
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Title: Annals of the Academy of Medicine, Singapore Volume: 29 ISSN: 0304-4602 ISO Abbreviation: Ann. Acad. Med. Singap. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2001-01-31 Completed Date: 2001-02-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503289 Medline TA: Ann Acad Med Singapore Country: SINGAPORE |
Other Details:
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Languages: eng Pagination: 442-6 Citation Subset: IM |
Affiliation:
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Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise Test* / instrumentation, methods Exercise Tolerance Female Heart Failure / diagnosis*, etiology, physiopathology, surgery* Heart Transplantation* Humans Male Middle Aged Patient Selection* Preoperative Care* Prognosis Respiratory Function Tests* / instrumentation, methods Stroke Volume Ventricular Function, Left Waiting Lists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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