Document Detail

Cardiopulmonary exercise testing in the functional and prognostic evaluation of patients with pulmonary diseases.
MedLine Citation:
PMID:  19145106     Owner:  NLM     Status:  MEDLINE    
Exercise testing is increasingly utilized to evaluate the level of exercise intolerance in patients with lung and heart diseases. Cardiopulmonary exercise testing (CPET) is considered the gold standard to study a patient's level of exercise limitation and its causes. The 2 CPET protocols most frequently used in the clinical setting are the maximal incremental and the constant work rate tests. The aim of this review is to focus on the main respiratory diseases for which exercise tolerance is indicated; for example, chronic obstructive pulmonary disease, interstitial lung disease, primary pulmonary hypertension and cystic fibrosis. This review also focuses on the variables/indices that are utilized in the functional and prognostic evaluation. The recognition of abnormal response patterns of ventilatory, cardiac and metabolic limitation to exercise may help in the diagnostic evaluation. In addition, CPET indexes can provide important functional and prognostic information regarding patients with pulmonary disease. Exercise indices, such as peak oxygen uptake (V'O(2 peak)), ventilatory equivalents for carbon dioxide production (V'(E)-/V'CO(2)) and arterial oxygen saturation (S(p)O(2)), have in fact proven to be better predictors of prognosis than lung function measurements obtained at rest. Moreover, useful information on the effects of therapeutic interventions may be obtained by CPET by studying the changes in endurance capacity during high-intensity constant work rate protocols.
A M Ferrazza; D Martolini; G Valli; P Palange
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-01-14
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  77     ISSN:  1423-0356     ISO Abbreviation:  Respiration     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-03-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3-17     Citation Subset:  IM    
Copyright Information:
(c) 2009 S. Karger AG, Basel.
Department of Clinical Medicine, Pulmonary Lung Function Unit, Sapienza University of Rome, Viale Università 37, Rome, Italy.
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MeSH Terms
Exercise / physiology
Exercise Test*
Lung Diseases / diagnosis*,  physiopathology
Oxygen Consumption
Pulmonary Gas Exchange

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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