| Cardiopulmonary exercise testing (CPET) in pulmonary emphysema. | |
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MedLine Citation:
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PMID: 21840426 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In patients affected by chronic obstructive pulmonary disease (COPD), cardiopulmonary response to exercise was never related to the severity of emphysema (E) measured by high resolution computed tomography (HRCT). Sixteen patients (age=65±8yrs; FEV(1)=54±18%pred; RV=160±28%pred) with moderate to severe E (quantified by lung HRCT as % voxels<-910 HU) were exercised on a cycle-ergometer to exhaustion. Oxygen uptake [Formula: see text] , carbon dioxide output [Formula: see text] , ventilation (V˙(E)), tidal volume (V(T)), and end-tidal [Formula: see text] ( [Formula: see text] ) derived variables were measured breath-by-breath. The % of E correlated with: (1) the ratio [Formula: see text] (r=0.74; p=0.001); (2) the [Formula: see text] slope (r=-0.77; p=0.0004); (3) [Formula: see text] values at peak exercise (r=0.80; p=0.0001). Also, the %E was strongly predicted by the following exercise equation: [Formula: see text] (r=0.94; p<0.0001). A [Formula: see text] ratio>1 is typically observed in severe E patients; furthermore, the [Formula: see text] slope and the [Formula: see text] values decrease and increase respectively as more as the emphysema is severe. |
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Authors:
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Patrizia Paoletti; Francesca De Filippis; Francesco Fraioli; Alessandra Cinquanta; Gabriele Valli; Pierantonio Laveneziana; Francesco Vaccaro; Dario Martolini; Paolo Palange |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-5 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: - ISSN: 1878-1519 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Department of Public Health and Infectious Diseases, Pulmonary Lung Function Unit, "La Sapienza" University, Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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