Document Detail

Cardiopulmonary exercise test predicts sustained ventricular arrhythmias in chronic heart failure.
MedLine Citation:
PMID:  23151817     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: The cardiopulmonary exercise test (CPX) is an affordable tool for risk prediction in patients with chronic heart failure (CHF). We aimed to determine the role of CPX parameters in predicting the risk of incidence of sustained ventricular arrhythmias (SVA) in CHF.
METHODS: Sixty-one consecutive patients with CHF enrolled in the Daunia Heart Failure Registry underwent CPX and were followed for 327 ± 247 days. Clinical follow-up was performed every month and anticipated in case of re-hospitalisation for cardiac disease. Incidence of SVA was evaluated by direct clinical examination (ECG, ambulatory ECG).
RESULTS: Patients with episodes of SVA (N 14) showed lower values of pVO2 and PetCO2, and higher values of VE/VCO2, VE/VCO2 slope, and VE%. After correction for age, gender, diabetes, ischaemic heart disease and left ventricular ejection fraction, peak VO2 (hazard ratio (HR) 0.68, 95 % confidence interval (CI) 0.51-0.91, p < 0.05), VE% (HR 1.38, 95 % CI 1.04-1.84, p < 0.05), VE/VCO2 (HR 1.38, 95 % CI 1.04-1.82, p < 0.05), VE/VCO2 slope (HR 1.77, 95 % CI 1.31-2.39, p < 0.01), PetCO2 (HR 0.66, 95 % CI 0.50-0.88, p < 0.01) were found as predictors of SVA. At Kaplan-Meier analysis, lower event-free rates were found in subjects with peak VO2 values below median (log rank p < 0.05), values of VE/VCO2 above mean (p < 0.05), higher VE/VCO2 slope tertiles (p <0.05), and values of PetCO2 below median (p < 0.05).
CONCLUSIONS: CPX provides prognostic independent information for risk of SVA in subjects with CHF.
M Correale; T Passero; A Totaro; C A Greco; F De Rosa; M Concilio; S Abbruzzese; G Acanfora; R Ieva; M Di Biase; N D Brunetti
Related Documents :
24773637 - Immediate and long-term outcome after angioplasty with stenting of the left main corona...
23590337 - Early impairment of contractility reserve in patients with insulin resistance in compar...
23672497 - Serum erythropoietin: a useful biomarker for coronary collateral development and potent...
25088437 - Effects of intensive glycaemic control on ischaemic heart disease: analysis of data fro...
7639327 - Prominence of coronary arterial wall lipids in human heart allografts. implications for...
20235167 - Anatomical observations of the moderator band.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation     Volume:  21     ISSN:  1568-5888     ISO Abbreviation:  Neth Heart J     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2012-12-25     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  101095458     Medline TA:  Neth Heart J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  36-43     Citation Subset:  -    
Department of Cardiology, University of Foggia, Viale Pinto 1, 71100, Foggia, Italy,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Barriers to Warfarin Use for Stroke Prevention in Patients With Atrial Fibrillation in Hong Kong.
Next Document:  NF-?B activation by equine arteritis virus is MyD88 dependent and promotes viral replication.