Document Detail

Cardiopulmonary exercise capacity, muscle strength, and physical activity in children and adolescents with achondroplasia.
MedLine Citation:
PMID:  17188608     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study in children with achondroplasia the response to exercise and muscle strength compared with healthy peers and to describe the relation between exercise capacity, anthropometric factors, and physical activity. STUDY DESIGN: Patients (7 boys and 10 girls; mean age, 11.8 +/- 3.3 years) with achondroplasia performed a maximal treadmill exercise test. Anthropometric variables and muscle strength were measured and compared with the general population. The level of everyday physical activity was measured by using a diary. Functional ability was measured by using the Activity Scale for Kids. RESULTS: The exercise capacity of the children with achondroplasia was significantly reduced compared with reference values. All anthropometrical measurements differed significantly from reference values. There was a decrease in muscle strength in almost all muscle groups. We found a reduced physical activity level and impairments in functional ability. CONCLUSIONS: Cardiopulmonary exercise capacity and muscle strength in children with achondroplasia was reduced compared with reference values. Children with achondroplasia have a unique response to exercise. Clinicians should take these characteristic differences into account when the exercise capacity of subjects with achondroplasia is being tested.
Tim Takken; Monique W M van Bergen; Ralph J B Sakkers; Paul J M Helders; Raoul H H Engelbert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  150     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  AIM; IM    
Department of Pediatric Physical Therapy and Exercise Physiology and the Department of Pediatric Orthopedics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. <>
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MeSH Terms
Achondroplasia / physiopathology*
Body Size
Exercise Tolerance / physiology*
Follow-Up Studies
Motor Activity / physiology*
Muscle Strength / physiology*
Risk Factors
Severity of Illness Index

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