| Cardiopulmonary effects of a new inspiratory impedance threshold device in anesthetized hypotensive dogs. | |
| | |
MedLine Citation:
|
PMID: 20230556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare the hemodynamic and respiratory effects of an inspiratory impedance threshold device (ITD) in anesthetized normotensive and hypotensive dogs. STUDY DESIGN: Prospective randomized study. ANIMALS: Ten adult dogs. METHODS: Dogs were anesthetized with propofol followed by isoflurane. During spontaneous ventilation, tidal volume (.VT), systolic (SAP), mean (MAP) and diastolic arterial blood pressure, central venous pressure, gastric PCO(2) as an indicator of gastric perfusion, subcutaneous oxygen tension, subcutaneous blood flow, cardiac index (CI), systemic vascular resistance and blood lactate were monitored. To monitor respiratory compliance (RC) and resistance (ResR), animals were briefly placed on mechanical ventilation. Dogs were studied under four different conditions: 1) normotension (MAP > 60 mmHg) with and without the ITD and 2) hypotension (target MAP = 40 mmHg) with and without ITD. These four conditions were performed during one anesthetic period, allowing for stabilization of parameters for each condition. Data were analyzed by anova repeated measure mixed models. RESULTS: No cardiovascular changes were detected between no ITD and ITD in the normotensive state. During hypotension, CI was higher with the ITD (5 +/- 1.0 L minute(-1) m(-2)) compared with no ITD (4 +/- 1.3 L minute(-1) m(-2)). During hypotension, SAP was increased with ITD (80 +/- 14 mmHg) versus without ITD (67 +/- 13 mmHg). There was an increase in ResR and decreased RC with the ITD in both normotensive and hypotensive state. CONCLUSION AND CLINICAL RELEVANCE: Impedance threshold device in dogs during isoflurane-induced hypotension improved CI and SAP but had negative effects on RC and ResR. |
| | |
Authors:
|
Andre C Shih; Alessio Vigani; Nichole Loring; Fernando G Pereira; Mark Szarowicz; Carsten Bandt |
Related Documents
:
|
16955826 - Preoperative administration of hydroxyethyl starch or hypertonic saline to horses with ... 3767036 - Cardiovascular effects of and interaction between calcium blocking drugs and anesthetic... 2310026 - Peripheral vascular effects of halothane and isoflurane in humans with an artificial he... 1359176 - Sympathetic vasoconstrictor tone induced by pentobarbital anesthesia in hindquarters of... 15590846 - Detrimental effects of overstuffing or understuffing with a radial head replacement in ... 12587466 - Sacral magnetic stimulation in puborectalis paradoxical syndrome. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-10 |
Journal Detail:
|
Title: Veterinary anaesthesia and analgesia Volume: 37 ISSN: 1467-2995 ISO Abbreviation: Vet Anaesth Analg Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-11 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100956422 Medline TA: Vet Anaesth Analg Country: England |
Other Details:
|
Languages: eng Pagination: 215-21 Citation Subset: IM |
Affiliation:
|
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA. shiha@vetmed.ufl.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia, Inhalation
/
adverse effects,
instrumentation,
veterinary* Animals Blood Pressure / physiology Cardiac Output Central Venous Pressure / physiology Dog Diseases / physiopathology* Dogs Heart Rate / physiology Hypotension / physiopathology, veterinary* Intubation, Intratracheal / instrumentation, veterinary* Isoflurane Lactates / blood Oxygen / blood Respiration Respiration, Artificial / veterinary Respiratory Rate / physiology Tidal Volume / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Lactates; 26675-46-7/Isoflurane; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication w...
Next Document: The hemodynamic effects of medetomidine continuous rate infusions in the dog.