Document Detail

Cardiopulmonary effects of nebulized sodium nitroprusside in term infants with hypoxic respiratory failure.
MedLine Citation:
PMID:  14615737     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study whether nebulized nitroprusside (neb-NP) improves oxygenation in term infants with hypoxic respiratory failure (HRF). STUDY DESIGN: We studied 22 newborn term infants (gestational age, 39.7+/-0.4 weeks [mean+/-SEM]; birth weight, 3.6+/-0.1 kg) with hypoxia (Pao2<100 mm Hg) during mechanical ventilation (Fio2=1.0). Sodium nitroprusside (5 mg followed by 25 mg) was nebulized into the inspiratory arm of the ventilator circuit. Vital signs and arterial blood gas values were recorded after 20 minutes at each dose and before and after initiation of inhaled nitric oxide (iNO). RESULTS: Pao2 increased significantly with 5 mg neb-NP (from 64.6+/-5.6 to 90.1+/-15.3 mm Hg, P=.04) and with 25 mg neb-NP (113.2+/-20.4 mm Hg, P=.009). Differences between mean Pao2 at 5 mg versus 25 mg neb-NP were also statistically significant (P=.03). When comparing the effect of neb-NP to iNO, the treatment-induced increases in Pao2 were similar (52.1+/-18.7 vs 62.2+/-18.2 mm Hg, respectively, P=not significant). CONCLUSIONS: Neb-NP causes a dose-dependent increase in oxygenation in term infants with HRF, similar in magnitude to iNO* Neb-NP may be beneficial in infants with HRF when iNO is not readily available.
Karen K L Mestan; Angela D Carlson; Melissa White; John A Powers; Sherwin Morgan; William Meadow; Michael D Schreiber
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  143     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  640-3     Citation Subset:  AIM; IM    
Department of Pediatrics, the University of Chicago Children's Hospital, Chicago, Illinois, USA.
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MeSH Terms
Administration, Inhalation
Anoxia / complications*,  diagnosis,  metabolism
Brain / metabolism
Dose-Response Relationship, Drug
Heart Rate / physiology*
Hemodynamics / physiology
Lung / physiopathology
Nitric Oxide / administration & dosage
Nitroprusside / administration & dosage,  therapeutic use*
Oxygen / metabolism
Prospective Studies
Respiratory Insufficiency / etiology*,  physiopathology,  therapy*
Vasodilator Agents / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 7782-44-7/Oxygen
Comment In:
J Pediatr. 2004 Oct;145(4):569; author reply 569   [PMID:  15480393 ]

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