| Cardiopulmonary effects of nebulized sodium nitroprusside in term infants with hypoxic respiratory failure. | |
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MedLine Citation:
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PMID: 14615737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study whether nebulized nitroprusside (neb-NP) improves oxygenation in term infants with hypoxic respiratory failure (HRF). STUDY DESIGN: We studied 22 newborn term infants (gestational age, 39.7+/-0.4 weeks [mean+/-SEM]; birth weight, 3.6+/-0.1 kg) with hypoxia (Pao2<100 mm Hg) during mechanical ventilation (Fio2=1.0). Sodium nitroprusside (5 mg followed by 25 mg) was nebulized into the inspiratory arm of the ventilator circuit. Vital signs and arterial blood gas values were recorded after 20 minutes at each dose and before and after initiation of inhaled nitric oxide (iNO). RESULTS: Pao2 increased significantly with 5 mg neb-NP (from 64.6+/-5.6 to 90.1+/-15.3 mm Hg, P=.04) and with 25 mg neb-NP (113.2+/-20.4 mm Hg, P=.009). Differences between mean Pao2 at 5 mg versus 25 mg neb-NP were also statistically significant (P=.03). When comparing the effect of neb-NP to iNO, the treatment-induced increases in Pao2 were similar (52.1+/-18.7 vs 62.2+/-18.2 mm Hg, respectively, P=not significant). CONCLUSIONS: Neb-NP causes a dose-dependent increase in oxygenation in term infants with HRF, similar in magnitude to iNO* Neb-NP may be beneficial in infants with HRF when iNO is not readily available. |
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Authors:
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Karen K L Mestan; Angela D Carlson; Melissa White; John A Powers; Sherwin Morgan; William Meadow; Michael D Schreiber |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 143 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-17 Completed Date: 2004-01-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 640-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, the University of Chicago Children's Hospital, Chicago, Illinois, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Anoxia / complications*, diagnosis, metabolism Brain / metabolism Dose-Response Relationship, Drug Female Heart Rate / physiology* Hemodynamics / physiology Humans Infant Lung / physiopathology Male Nitric Oxide / administration & dosage Nitroprusside / administration & dosage, therapeutic use* Oximetry Oxygen / metabolism Prospective Studies Respiratory Insufficiency / etiology*, physiopathology, therapy* Vasodilator Agents / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2004 Oct;145(4):569; author reply 569
[PMID:
15480393
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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