| Cardiopulmonary effects in awake rats four and six months after exposure to methyl isocyanate. | |
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MedLine Citation:
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PMID: 2957196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiopulmonary function was assessed four and six months after Fischer 344 rats were exposed to 2 hr to 0, 3, or 10 ppm methyl isocyanate (MIC). During assessment, the rats were challenged with 4 and 8% carbon dioxide (CO2) to stimulate ventilatory drive. Minute ventilation (VE) during CO2 challenge was increased in MIC-treated rats compared to controls when examined 4 months after exposure to 10 ppm MIC, suggesting a ventilation/perfusion inequality. An increase in maximum expiratory flow and a decrease in expiratory time indicated increased lung recoil in these rats. Evidence of pulmonary hypertension was observed in electrocardiograms (ECGs) and supported by postmortem analysis that showed a positive association between increased ECG abnormalities and increased right ventricular weights in the rats treated with 10 ppm MIC. At 6 months, forced expiratory flow-volume curves indicated persistent airway obstruction; however, no changes in inspiratory or expiratory resistance were evident. Decreased dynamic compliance and changes in two new measures of lung function (volume and time at zero expiratory intrapleural pressure) suggest that MIC-induced lung dysfunction also exhibited elements of a restrictive disease. |
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Authors:
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J S Tepper; M J Wiester; D L Costa; W P Watkinson; M F Weber |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Environmental health perspectives Volume: 72 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-10-19 Completed Date: 1987-10-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 95-103 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Obstruction
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chemically induced Airway Resistance / drug effects Animals Cardiomegaly / chemically induced Cardiovascular System / drug effects*, physiopathology Cyanates / administration & dosage, toxicity* Electrocardiography Hypertension, Pulmonary / chemically induced Isocyanates* Lung / drug effects*, physiopathology Lung Compliance / drug effects Male Rats Rats, Inbred F344 Respiration / drug effects Tidal Volume Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cyanates; 0/Isocyanates; 624-83-9/methyl isocyanate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 6 Year: 1987 Volume: 72First Page: 95 Last Page: 103 ID: 1474643 PubMed Id: 2957196 |
| Cardiopulmonary effects in awake rats four and six months after exposure to methyl isocyanate. | |
| J S Tepper | |
| M J Wiester | |
| D L Costa | |
| W P Watkinson | |
| M F Weber | |
Article Categories:
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