Document Detail


Cardiopulmonary effects of dobutamine and norepinephrine infusion in healthy anesthetized alpacas.
MedLine Citation:
PMID:  19827986     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective-To characterize the cardiopulmonary effects of dobutamine and norepinephrine infusion in isoflurane-anesthetized healthy alpacas. Animals-8 adult alpacas. Procedures-Initial baseline cardiovascular, respiratory, and metabolic variables were obtained 30 minutes after induction of isoflurane anesthesia in 8 alpacas (3 females and 5 sexually intact males). Four treatments (dobutamine at 4 and 8 mug/kg/min and norepinephrine at 0.3 and 1 mug/kg/min) were administered in random order via constant rate infusion over 15 minutes, followed by repeat measurements of cardiopulmonary values and a 20-minute washout period. Subsequent baseline and posttreatment measurements were similarly repeated until both drugs and dosages were administered to each animal. Baseline data in awake alpacas were obtained 18 to 24 hours following recovery from anesthesia. Results-Both dobutamine and norepinephrine significantly increased cardiac index and arterial blood pressure from baseline values. Similar increases in hemoglobin concentration, oxygen content, and oxygen delivery were observed following administration of each drug at either dosage. Only dobutamine, however, reduced relative oxygen consumption while improving overall tissue oxygenation. Furthermore, heart rate was selectively enhanced by dobutamine and systemic vascular resistance by norepinephrine. Norepinephrine infusion resulted in dose-dependent changes in cardiopulmonary variables. Conclusions and Clinical Relevance-Results indicated that both dobutamine and norepinephrine are appropriate choices to improve cardiac index, mean arterial pressure, and overall oxygen delivery in alpacas with isoflurane-induced hypotension. Careful titration, by use of low infusion rates of dobutamine and norepinephrine, is recommended to avoid potential arrhythmogenic effects and excessive vasoconstriction, respectively. (Am J Vet Res 2009;70:1236-1242).
Authors:
Caitlin J Vincent; Alexander T Hawley; Elizabeth A Rozanski; Kara M Lascola; Daniela Bedenice
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  235     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  981     Citation Subset:  IM    
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