| Cardiopulmonary bypass increases permeability of the blood-cerebrospinal fluid barrier. | |
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MedLine Citation:
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PMID: 20103233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The integrity of the blood-cerebrospinal fluid (CSF) barrier during cardiopulmonary bypass (CPB) with hypothermic circulatory arrest (HCA) has not been systematically studied, especially in children. We tested the hypothesis that the blood-CSF barrier is disrupted by CPB. METHODS: The study randomized 25 piglets (mean weight, 11 kg) to five groups (5 per group): anesthesia alone (control); CPB at 37 degrees C with full-flow (FF); CPB at 25 degrees C with very low flow (LF); and HCA at 15 degrees C and 25 degrees C. pH-stat strategy was applied during CPB. An epidural catheter was inserted into the cisterna magna for collection of CSF. CSF and blood samples were collected at seven points: after induction of anesthesia (baseline), at 10, 50 and 115 minutes after start of CPB, just before the end of CPB, and at 30 and 120 minutes after CPB. Albumin levels in CSF and plasma were measured to assess blood-CSF barrier integrity and the albumin ratio (CSF/plasma) was calculated (Q(Alb)). RESULTS: In both HCA groups, the Q(Alb) was significantly higher than in the control and 37 degrees C FF groups (all p < 0.05), whereas Q(Alb) in the 37 degrees C group was not significantly different vs control. CONCLUSIONS: The blood-CSF barrier is impaired by CPB with 1 hour of 15 degrees C or 25 degrees C HCA. Further investigations are needed to understand the behavior of the blood-CSF barrier during CPB and its role in neuroprotection. |
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Authors:
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Toru Okamura; Nobuyuki Ishibashi; David Zurakowski; Richard A Jonas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 89 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-03-04 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 187-94 Citation Subset: AIM; IM |
Copyright Information:
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2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cardiovascular Surgery, Children's National Medical Center, Washington, DC 20010, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / physiology* Cardiopulmonary Bypass* Cerebrospinal Fluid Proteins / blood* Disease Models, Animal Oxygen / blood, cerebrospinal fluid Serum Albumin / cerebrospinal fluid* Swine |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL060922-09/HL/NHLBI NIH HHS; R01-HL060922/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cerebrospinal Fluid Proteins; 0/Serum Albumin; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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