| Cardiopulmonary bypass in a model of acute myocardial infarction and cardiac arrest. | |
| | |
MedLine Citation:
|
PMID: 2372169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cardiopulmonary bypass (CPB) reperfusion has demonstrated improved resuscitation rates in ventricular fibrillation cardiac arrest models. To investigate the effectiveness of CPB reperfusion in an ischemic cardiac arrest setting, simulating the clinical scenario of myocardial ischemia preceding sudden cardiac death, we developed a canine model of acute myocardial infarction followed by ventricular fibrillation. Sixteen dogs were randomly assigned to two groups. Group 1 (eight) had ventricular fibrillation induced without left anterior descending coronary artery occlusion. Group 2 (eight) had a thrombogenic copper coil placed in the left anterior descending artery and showed ECG evidence of acute myocardial infarction before induction of ventricular fibrillation. CPR commenced after eight minutes of ventricular fibrillation. Epinephrine 0.05 mg/kg and NaHCO3 1.0 mEq/kg were administered at ten minutes. CPB was begun at 12 minutes and continued for one hour. Myocardial ischemic and necrotic areas were determined in four-hour survivors by dual histochemical staining. All animals were resuscitated; all eight group 1 and six of eight group 2 animals survived to four hours. With the onset of CPB, coronary perfusion pressures increased significantly by 68.6 +/- 31.8 (SD) mm Hg in group 1 and 56.2 +/- 34.6 mm Hg in group 2 over those obtained with CPR (P less than .001).(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
M G Angelos; M Gaddis; G Gaddis; J E Leasure |
Related Documents
:
|
7156929 - Myocardial preservation during anoxic arrest. experimental model ventricular fibrillation. 19646269 - A survey of factors associated with the successful recognition of agonal breathing and ... 1421609 - Cardiac pathology following resuscitative circulatory support. direct mechanical ventri... 703359 - Quantitative evaluation of myocardial ultrastructure following hypothermic anoxic arrest. 9305429 - Vasopressin can increase coronary perfusion pressure during human cardiopulmonary resus... 11162009 - A biomechanical analysis of intrascaphoid compression using the 3.00 mm synthes cannula... 21366469 - Malignant pericardial effusion. 17029919 - The pathology of the heart conduction system in congenital heart block. 9149549 - Cardiac fibroma presenting as sudden death in a six-month-old infant. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of emergency medicine Volume: 19 ISSN: 0196-0644 ISO Abbreviation: Ann Emerg Med Publication Date: 1990 Aug |
Date Detail:
|
Created Date: 1990-08-23 Completed Date: 1990-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8002646 Medline TA: Ann Emerg Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 874-80 Citation Subset: AIM; IM |
Affiliation:
|
Department of Emergency Medicine, Wright State University School of Dayton, Ohio 45401-0927. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiopulmonary Bypass* Coronary Disease / therapy* Dogs Heart Arrest / therapy* Models, Biological Myocardial Infarction / therapy* Pulmonary Gas Exchange Resuscitation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preventability of malpractice claims in emergency medicine: a closed claims study.
Next Document: The effectiveness of bystander CPR in an animal model.