| Cardiopulmonary bypass in ewe's fetus: advances and setbacks in our learning curve. | |
| | |
MedLine Citation:
|
PMID: 16322732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fetal cardiac surgery represents a surgical challenge and several centers are attempting to establish a suitable methodology in animals. We present our experience with extra-corporeal bypass procedures in preterm and term sheep fetuses. Twenty-two fetuses (103-139 days gestation, mean 115 days gestation) underwent a 1-hour period of right heart-to-pulmonary artery extracorporeal circulation followed by 1 hour of observation. Animals were divided into group 1 and group 2, according to gestational age (above and below 0.85). Three pumps were used: centrifugal without (group 1) reservoir, centrifugal with (group 2) reservoir, and roller with reservoir (group 2). Experiments were completed in 75% of fetuses in group 1 and in 37% of fetuses in group 2. Bleeding was the main cause of failure, especially for group 2. A slow deterioration of blood gas status was noted in group 1, while this trend could be partially reversed in group 2 with corrective measures. Complete heart bypass could not be achieved in either group, and residual fluctuations in arterial pressure were observed. During bypass, body temperature decreased more in group 2 than in group 1. We conclude that cardiac bypass is feasible over a short period in near-term fetuses. A successful outcome may also be obtained in younger fetuses, but better measures need to be implemented for the prevention of surgical bleeding. |
| | |
Authors:
|
A Crucean; B Murzi; A Giorgi; S Burchielli; M Trivella; F Coceani |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 51 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2005 Sep-Oct |
Date Detail:
|
Created Date: 2005-12-08 Completed Date: 2006-02-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
|
Languages: eng Pagination: 649-53 Citation Subset: IM |
Affiliation:
|
G Pasquinucci Hospital for Cardiac Surgery, Massa, Italy. disor99@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Gas Analysis Blood Loss, Surgical / prevention & control Body Temperature Cardiopulmonary Bypass / trends* Extracorporeal Circulation / adverse effects, instrumentation*, methods Feasibility Studies Female Fetal Blood / chemistry Fetus / surgery* Gestational Age Pregnancy Sheep |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vacuum-assisted venous drainage during fetal cardiopulmonary bypass.
Next Document: Technique and results for integration of the quest MPS all-blood cardioplegia delivery unit for modi...