Document Detail

Cardiopulmonary bypass in ewe's fetus: advances and setbacks in our learning curve.
MedLine Citation:
PMID:  16322732     Owner:  NLM     Status:  MEDLINE    
Fetal cardiac surgery represents a surgical challenge and several centers are attempting to establish a suitable methodology in animals. We present our experience with extra-corporeal bypass procedures in preterm and term sheep fetuses. Twenty-two fetuses (103-139 days gestation, mean 115 days gestation) underwent a 1-hour period of right heart-to-pulmonary artery extracorporeal circulation followed by 1 hour of observation. Animals were divided into group 1 and group 2, according to gestational age (above and below 0.85). Three pumps were used: centrifugal without (group 1) reservoir, centrifugal with (group 2) reservoir, and roller with reservoir (group 2). Experiments were completed in 75% of fetuses in group 1 and in 37% of fetuses in group 2. Bleeding was the main cause of failure, especially for group 2. A slow deterioration of blood gas status was noted in group 1, while this trend could be partially reversed in group 2 with corrective measures. Complete heart bypass could not be achieved in either group, and residual fluctuations in arterial pressure were observed. During bypass, body temperature decreased more in group 2 than in group 1. We conclude that cardiac bypass is feasible over a short period in near-term fetuses. A successful outcome may also be obtained in younger fetuses, but better measures need to be implemented for the prevention of surgical bleeding.
A Crucean; B Murzi; A Giorgi; S Burchielli; M Trivella; F Coceani
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  51     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-12-08     Completed Date:  2006-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649-53     Citation Subset:  IM    
G Pasquinucci Hospital for Cardiac Surgery, Massa, Italy.
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MeSH Terms
Blood Gas Analysis
Blood Loss, Surgical / prevention & control
Body Temperature
Cardiopulmonary Bypass / trends*
Extracorporeal Circulation / adverse effects,  instrumentation*,  methods
Feasibility Studies
Fetal Blood / chemistry
Fetus / surgery*
Gestational Age

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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