Document Detail


Cardiopulmonary, blood and peritoneal fluid alterations associated with abdominal insufflation of carbon dioxide in standing horses.
MedLine Citation:
PMID:  12755432     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
REASONS FOR PERFORMING STUDY: Abdominal insufflation is performed routinely during laparoscopy in horses to improve visualisation and facilitate instrument and visceral manipulations during surgery. It has been shown that high-pressure pneumoperitoneum with carbon dioxide (CO2) has deleterious cardiopulmonary effects in dorsally recumbent, mechanically ventilated, halothane-anaesthetised horses. There is no information on the effects of CO2 pneumoperitoneum on cardiopulmonary function and haematology, plasma chemistry and peritoneal fluid (PF) variables in standing sedated horses during laparoscopic surgery. OBJECTIVES: To determine the effects of high pressure CO2 pneumoperitoneum in standing sedated horses on cardiopulmonary function, blood gas, haematology, plasma chemistry and PF variables. METHODS: Six healthy, mature horses were sedated with an i.v. bolus of detomidine (0.02 mg/kg bwt) and butorphanol (0.02 mg/kg bwt) and instrumented to determine the changes in cardiopulmonary function, haematology, serum chemistry and PF values during and after pneumoperitoneum with CO2 to 15 mmHg pressure for standing laparoscopy. Each horse was assigned at random to either a standing left flank exploratory laparoscopy (LFL) with CO2 pneumoperitoneum or sham procedure (SLFL) without insufflation, and instrumented for measurement of cardiopulmonary variables. Each horse underwent a second procedure in crossover fashion one month later so that all 6 horses had both an LFL and SLFL performed. Cardiopulmonary variables and blood gas analyses were obtained 5 mins after sedation and every 15 mins during 60 mins baseline (BL), insufflation (15 mmHg) and desufflation. Haematology, serum chemistry analysis and PF analysis were performed at BL, insufflation and desufflation, and 24 h after the conclusion of each procedure. RESULTS: Significant decreases in heart rate, cardiac output and cardiac index and significant increases in mean right atrial pressure, systemic vascular resistance and pulmonary vascular resistance were recorded immediately after and during sedation in both groups of horses. Pneumoperitoneum with CO2 at 15 mmHg had no significant effect on cardiopulmonary function during surgery. There were no significant differences in blood gas, haematology or plasma chemistry values within or between groups at any time interval during the study. There was a significant increase in the PF total nucleated cell count 24 h following LFL compared to baseline values for LFL or SLFL at 24 h. There were no differences in PF protein concentrations within or between groups at any time interval. CONCLUSIONS: Pneumoperitoneum with CO2 during standing laparoscopy in healthy horses does not cause adverse alterations in cardiopulmonary, haematology or plasma chemistry variables, but does induce a mild inflammatory response within the peritoneal cavity. POTENTIAL RELEVANCE: High pressure (15 mmHg) pneumoperitoneum in standing sedated mature horses for laparoscopic surgery can be performed safely without any short-term or cumulative adverse effects on haemodynamic or cardiopulmonary function.
Authors:
F G Latimer; S C Eades; G Pettifer; J Tetens; G Hosgood; R M Moore
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  35     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-20     Completed Date:  2003-10-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  283-90     Citation Subset:  IM    
Affiliation:
Equine Health Studies Program, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ascitic Fluid / chemistry,  cytology,  veterinary*
Blood Gas Analysis / veterinary
Carbon Dioxide / administration & dosage,  adverse effects*
Cardiac Output / drug effects,  physiology
Conscious Sedation / veterinary
Cross-Over Studies
Female
Heart / drug effects*,  physiology
Hemodynamics / drug effects,  physiology
Homeostasis / drug effects*,  physiology
Horses / physiology*
Insufflation / adverse effects,  methods,  veterinary*
Laparoscopy / veterinary
Male
Peritoneal Cavity / pathology
Pneumoperitoneum / chemically induced,  physiopathology,  veterinary*
Random Allocation
Respiration
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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