Document Detail

Cardiopulmonary and acid-base effects of desflurane and sevoflurane in spontaneously breathing cats.
MedLine Citation:
PMID:  15771945     Owner:  NLM     Status:  MEDLINE    
The cardiopulmonary effects of desflurane and sevoflurane anesthesia were compared in cats breathing spontaneously. Heart (HR) and respiratory (RR) rates; systolic (SAP), diastolic (DAP) and mean arterial (MAP) pressures; partial pressure of end tidal carbon dioxide (PETCO2), arterial blood pH (pH), arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2); base deficit (BD), arterial oxygen saturation (SaO2) and bicarbonate ion concentration (HCO3) were measured. Anesthesia was induced with propofol (8+/-2.3mg/kg IV) and maintained with desflurane (GD) or sevoflurane (GS), both at 1.3 MAC. Data were analyzed by analysis of variance (ANOVA), followed by the Tukey test (P<0.05). Both anesthetics showed similar effects. HR and RR decreased when compared to the basal values, but remained constant during inhalant anesthesia and PETCO2 increased with time. Both anesthetics caused acidemia and hypercapnia, but BD stayed within normal limits. Therefore, despite reducing HR and SAP (GD) when compared to the basal values, desflurane and sevoflurane provide good stability of the cardiovascular parameters during a short period of inhalant anesthesia (T20-T60). However, both volatile anesthetics cause acute respiratory acidosis in cats breathing spontaneously.
Almir Pereira Souza; Piedad Natalia Henao Guerrero; Celina Tie Nishimori; Danielli Parrilha Paula; Paulo Sergio Patto Santos; Marlis Langenegger de Rezende; Newton Nunes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of feline medicine and surgery     Volume:  7     ISSN:  1098-612X     ISO Abbreviation:  J. Feline Med. Surg.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-17     Completed Date:  2005-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100897329     Medline TA:  J Feline Med Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Department of Veterinary Clinics and Surgery, Veterinary Surgery Program, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Rod. Professor Paulo Donato Castelane, s/n. CEP: 14884-900, Jaboticabal, SP., Brazil.
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MeSH Terms
Acid-Base Equilibrium / drug effects*
Analysis of Variance
Anesthesia, Inhalation / veterinary*
Anesthetics, Inhalation / pharmacology*
Cardiac Output / drug effects
Cardiovascular System / drug effects*
Cerebrovascular Circulation / drug effects
Heart Rate / drug effects
Isoflurane / analogs & derivatives*,  pharmacology*
Methyl Ethers / pharmacology*
Oxygen Consumption / drug effects
Partial Pressure
Pulmonary Artery / drug effects
Random Allocation
Respiration / drug effects*
Stroke Volume / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane

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