| Cardiopulmonary and acid-base effects of desflurane and sevoflurane in spontaneously breathing cats. | |
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MedLine Citation:
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PMID: 15771945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiopulmonary effects of desflurane and sevoflurane anesthesia were compared in cats breathing spontaneously. Heart (HR) and respiratory (RR) rates; systolic (SAP), diastolic (DAP) and mean arterial (MAP) pressures; partial pressure of end tidal carbon dioxide (PETCO2), arterial blood pH (pH), arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2); base deficit (BD), arterial oxygen saturation (SaO2) and bicarbonate ion concentration (HCO3) were measured. Anesthesia was induced with propofol (8+/-2.3mg/kg IV) and maintained with desflurane (GD) or sevoflurane (GS), both at 1.3 MAC. Data were analyzed by analysis of variance (ANOVA), followed by the Tukey test (P<0.05). Both anesthetics showed similar effects. HR and RR decreased when compared to the basal values, but remained constant during inhalant anesthesia and PETCO2 increased with time. Both anesthetics caused acidemia and hypercapnia, but BD stayed within normal limits. Therefore, despite reducing HR and SAP (GD) when compared to the basal values, desflurane and sevoflurane provide good stability of the cardiovascular parameters during a short period of inhalant anesthesia (T20-T60). However, both volatile anesthetics cause acute respiratory acidosis in cats breathing spontaneously. |
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Authors:
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Almir Pereira Souza; Piedad Natalia Henao Guerrero; Celina Tie Nishimori; Danielli Parrilha Paula; Paulo Sergio Patto Santos; Marlis Langenegger de Rezende; Newton Nunes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of feline medicine and surgery Volume: 7 ISSN: 1098-612X ISO Abbreviation: J. Feline Med. Surg. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-17 Completed Date: 2005-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100897329 Medline TA: J Feline Med Surg Country: England |
Other Details:
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Languages: eng Pagination: 95-100 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinics and Surgery, Veterinary Surgery Program, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Rod. Professor Paulo Donato Castelane, s/n. CEP: 14884-900, Jaboticabal, SP., Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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drug effects* Analysis of Variance Anesthesia, Inhalation / veterinary* Anesthetics, Inhalation / pharmacology* Animals Cardiac Output / drug effects Cardiovascular System / drug effects* Cats Cerebrovascular Circulation / drug effects Heart Rate / drug effects Isoflurane / analogs & derivatives*, pharmacology* Methyl Ethers / pharmacology* Oxygen Consumption / drug effects Partial Pressure Pulmonary Artery / drug effects Random Allocation Respiration / drug effects* Stroke Volume / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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