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Cardiopulmonary Variables During Exercise Predict Pregnancy Outcome in Women With Congenital Heart Disease.
MedLine Citation:
PMID:  23059769     Owner:  NLM     Status:  Publisher    
Background: Maternal New York Heart Association (NYHA) class is associated with pregnancy outcome in women with congenital heart disease (WCHD), but objective predictive criteria of exercise capacity have not been established. Methods and Results: A total of 33 WCHD (age, 28±5 years; NYHA class, 1.3±0.6) who had undergone cardiopulmonary exercise testing (CPX) 1.8±2.2 years before their delivery were retrospectively identified. Maternal, cardiac, and neonatal events occurred in 8 (24%), 12 (36%), and 14 (42%), respectively. All CPX parameters correlated with neonatal birth weight (P<0.05-0.001). Exercise time, peak heart rate (HR), peak systolic blood pressure, and peak oxygen uptake (VO(2)) were associated with cardiac events (P<0.05-0.01), and exercise time and peak VO(2) were also associated with neonatal events (P<0.05). Exercise time, peak HR, and peak VO(2) were associated with at least 1 of the 3 events (P<0.05-0.01). Receiver operating characteristic analysis showed that peak HR <150beats/min and/or peak VO(2) <22.0ml·kg(-1)·min(-1), peak VO(2) <26.2ml·kg(-1)·min(-1), and peak HR <150beats/min and/or peak VO(2) <25.3ml·kg(-1)·min(-1) predicted a high probability of maternal cardiac, neonatal, and maternal cardiac and/or neonatal event, respectively. Conclusions: CPX parameters predict pregnancy outcome and peak HR ≥150beats/min and/or peak VO(2) ≥25ml·kg(-1)·min(-1) may be reference value(s) for a safer pregnancy outcome in WCHD.
Hideo Ohuchi; Yuka Tanabe; Chizuko Kamiya; Kanae Noritake; Kenji Yasuda; Aya Miyazaki; Tomoaki Ikeda; Osamu Yamada
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center.
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