Document Detail


Cardiopulmonary toxicity of different chemoradiotherapy combined regimens for Hodgkin's disease.
MedLine Citation:
PMID:  21036768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PATIENTS AND METHODS: We investigated 147 patients suffering from Hodgkin's disease after a follow-up of at least 5 years from the completion of CT-RT. Seventy-eight patients were submitted to ABVD-RT, 36 to VEBEP-RT and 33 to MOPP-ABVD-RT. Patients underwent spirometry, 2D-doppler echocardiography at rest, cardiopulmonary exercise test on cycloergometer and determination of cardiac output by a non invasive method.
RESULTS: Patients of the three different treatment groups showed tolerance to exercise, and oxygen consumption significantly lower than the predicted values but there were no statistically significant difference between the three groups. Nevertheless, patients treated with VEBEP and with MOPP-ABVD showed an ejection fraction at rest lower than those observed in the ABVD group and patients treated with VEBEP showed a cardiac output for oxygen uptake lower than those observed in the ABVD and MOPP-ABVD treatment groups.
CONCLUSION: These data confirm that the combination of mediastinal RT with the more commonly used polychemotherapy regimens produce late toxic effects. The lower exercise capacity seems to be due to a combination of decreased cardiac performance and impairment of ventilation. The VEBEP regimens could be potentially more toxic for the heart, probably because of the higher cumulative dose of anthracyclines.
Authors:
Alessandra Busia; Alberto Laffranchi; Simonetta Viviani; Valeria Bonfante; Fabrizio Villani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  4381-7     Citation Subset:  IM    
Affiliation:
UO Pneumologia e Fisiopatologia Respiratoria Fondazione IRCCS, Istituto Nazionale dei Tumori, Milano, Italy. alessandra.busia@istitutotumori.mi.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  adverse effects*,  therapeutic use
Bleomycin / administration & dosage,  adverse effects
Cardiovascular Diseases / chemically induced,  etiology*,  metabolism,  physiopathology
Combined Modality Therapy / adverse effects
Cyclophosphamide / administration & dosage,  adverse effects
Dacarbazine / administration & dosage,  adverse effects
Doxorubicin / administration & dosage,  adverse effects
Epirubicin / administration & dosage,  adverse effects
Etoposide / administration & dosage,  adverse effects
Female
Hodgkin Disease / drug therapy*,  metabolism,  physiopathology,  radiotherapy*
Humans
Lung Diseases / chemically induced,  etiology*,  metabolism,  physiopathology
Male
Mechlorethamine / administration & dosage,  adverse effects
Middle Aged
Oxygen Consumption / drug effects
Prednisone / administration & dosage,  adverse effects
Procarbazine / administration & dosage,  adverse effects
Radiation Injuries / etiology*
Radiotherapy / adverse effects
Vinblastine / administration & dosage,  adverse effects
Vincristine / administration & dosage,  adverse effects
Young Adult
Chemical
Reg. No./Substance:
11056-06-7/Bleomycin; 23214-92-8/Doxorubicin; 33419-42-0/Etoposide; 4342-03-4/Dacarbazine; 50-18-0/Cyclophosphamide; 51-75-2/Mechlorethamine; 53-03-2/Prednisone; 56420-45-2/Epirubicin; 57-22-7/Vincristine; 671-16-9/Procarbazine; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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