Document Detail

Cardiopulmonary Rehabilitation Enhances Heart Rate Recovery in Patients with COPD.
MedLine Citation:
PMID:  22710548     Owner:  NLM     Status:  Publisher    
BACKGROUND: Autonomic dysfunction is present early in the course of chronic obstructive pulmonary disease (COPD) and is associated with adverse outcomes. We utilized heart rate recovery, a simple and validated index of autonomic balance, to investigate the effects of exercise training on autonomic dysfunction in patients with COPD. METHODS: We evaluated 45 stable patients with COPD who participated in a 36-session exercise-based cardiopulmonary rehabilitation program. Patients underwent maximal cardiopulmonary exercise testing at baseline and after completion of the rehabilitation program. We recorded exercise testing parameters and heart rate during rest, exercise, and recovery; heart rate recovery was calculated as heart rate at peak exercise minus heart rate at the first minute of recovery. RESULTS: Thirty-nine patients (age, 66.3±7.8 years; 90% male; body mass index, 27.1±4.1 kg/m2; forced expiratory volume in 1st sec [FEV₁], 45.7±18.7%) completed the program. In these patients, heart rate recovery increased from 16.2±8.0 to 18.4±8.4 beats/min (p<0.05), resting heart rate decreased from 88.0±10.7 to 83.3±10.3 beats/min (p<0.01), and heart rate at anaerobic threshold decreased from 109.0±12.3 to 105.5±11.7 beats/min (p<0.05). In addition, oxygen consumption (VO₂) increased from 14.3±3.7 to 15.2±3.8 mL/kg/min at peak exercise and from 9.7±2.4 to 10.4±2.5 mL/kg/min at anaerobic threshold (both p<0.05), while the VO₂/t slope increased from -0.32±0.16 to -0.38±0.19 mL/kg/min² (p<0.01); parameters of ventilatory performance improved also. CONCLUSIONS: In patients with COPD, exercise-based rehabilitation improves heartrate recovery, modestly though, which indicates a degree of attenuated autonomic dysfunction. Exercise and muscular oxidative capacity, as expressed by VO₂/t slope, are also improved.
Vasiliki V Georgiopoulou; Stavros Dimopoulos; Dimitrios Sakellariou; Ourania Papazachou; Vasiliki Gerovasili; Athanasios Tasoulis; Varvara Agapitou; Ioannis Vogiatzis; Charis Roussos; Serafim Nanas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-15
Journal Detail:
Title:  Respiratory care     Volume:  -     ISSN:  0020-1324     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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