Document Detail

Cardioprotective mechanisms activated in response to myocardial ischemia.
MedLine Citation:
PMID:  22338709     Owner:  NLM     Status:  In-Process    
Myocardial ischemia, a disorder causing myocardial infarction and malfunction, can activate various adaptive mechanisms that protect cardiomyocytes from ischemic injury. During the early hours post myocardial ischemia, injured cardiac cells can release several molecules, including adenosine, opioids, and bradykinin, which promote myocardial survival by activating the G protein signaling pathways. During a later phase about several days, myocardial ischemia induces upregulation of growth factors and cytokines, including VEGF, ILGF, HGF, and SDF-1, in the injured myocardium, contributing to cardioprotection. In addition to the injured heart, the liver participates in cardioprotection. In response to myocardial ischemia, the liver upregulates and releases secretory proteins, including FGF21 and TFF3, both of which promote cardiomyocyte survival. The liver also provides a reservoir of hepatic cells that mobilize to the site of myocardial ischemia, potentially contributing to cardioprotection. Taken together, the early and late mechanisms act coordinately in a time-dependent manner, ensuring effective cardioprotection post myocardial infarction. Investigations on these innate cardioprotective mechanisms have provided insights into the development of cardioprotective strategies for treating myocardial infarction. In this article, the authors review the innate mechanisms of cardioprotection in myocardial ischemia.
Shu Q Liu; Brandon J Tefft; Di Zhang; Derek Roberts; Daniel J Schuster; Allison Wu
Related Documents :
22811779 - The effect of gag reflex on cardiac sympatovagal tone.
18052899 - The left heart can only be as good as the right heart: determinants of function and dys...
21760969 - Synergism between arrhythmia and hyperhomo-cysteinemia in structural heart disease.
21911319 - Comparative diagnostic accuracy of serum levels of neutrophil activating peptide-2 and ...
3078539 - Echocardiography in congestive or dilated cardiomyopathy.
21656599 - Astragalosides rescue both cardiac function and sarcoplasmic reticulum ca(2+) transport...
8606419 - New technology in wound ballistics: the doppler radar.
3788809 - Frequency of complications of mitral valve prolapse in subjects aged 60 years and older.
14668889 - Cardiological syndrome x. non-invasive assessment of endothelial function and arterial ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular & cellular biomechanics : MCB     Volume:  8     ISSN:  1556-5297     ISO Abbreviation:  Mol Cell Biomech     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101253756     Medline TA:  Mol Cell Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-38     Citation Subset:  IM    
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208-3107, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Structure-function relationships in the stem cell's mechanical world B: emergent anisotropy of the c...
Next Document:  Reconnecting to the biosphere.