| Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats. | |
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MedLine Citation:
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PMID: 19530445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tanshinone IIA (Tan IIA), a derivative of phenanthrenequinone isolated from Salvia miltiorrhiza, has been widely used for treating cardiovascular diseases in China. In the present study, we assessed the effect of Tan IIA on cardiac function, vascular endothelial growth factor (VEGF) expression and angiogenesis on models of myocardial infarction (MI) in rats. The results demonstrated that TanIIA elicited a significantly cardioprotective effect by improving heart function, reducing infarct size, and increasing survival rate in MI rat. Our results offer, for the first time, further insight into Tan IIA promoting angiogenesis and up-regulating VEGF expression in MI rats due to the enhancement of hypoxia-inducible factor 1alpha mRNA expression, and provide a novel target for Tan IIA in the prevention and treatment of myocardial ischemia injury. |
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Authors:
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Wei Xu; Jun Yang; Li-Mao Wu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Die Pharmazie Volume: 64 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-06-17 Completed Date: 2009-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 332-6 Citation Subset: IM |
Affiliation:
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Institute of Chinese Herb Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Cardiotonic Agents / pharmacology* Heart / drug effects Hemodynamics / drug effects Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis Immunohistochemistry Male Myocardial Infarction / drug therapy*, pathology Myocardium / pathology Phenanthrenes / pharmacology* RNA, Messenger / biosynthesis Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Thiobarbituric Acid Reactive Substances / metabolism Vascular Endothelial Growth Factor A / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Cardiotonic Agents; 0/Hif1a protein, rat; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Phenanthrenes; 0/RNA, Messenger; 0/Thiobarbituric Acid Reactive Substances; 0/Vascular Endothelial Growth Factor A; 568-73-0/tanshinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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