Document Detail


Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats.
MedLine Citation:
PMID:  19530445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tanshinone IIA (Tan IIA), a derivative of phenanthrenequinone isolated from Salvia miltiorrhiza, has been widely used for treating cardiovascular diseases in China. In the present study, we assessed the effect of Tan IIA on cardiac function, vascular endothelial growth factor (VEGF) expression and angiogenesis on models of myocardial infarction (MI) in rats. The results demonstrated that TanIIA elicited a significantly cardioprotective effect by improving heart function, reducing infarct size, and increasing survival rate in MI rat. Our results offer, for the first time, further insight into Tan IIA promoting angiogenesis and up-regulating VEGF expression in MI rats due to the enhancement of hypoxia-inducible factor 1alpha mRNA expression, and provide a novel target for Tan IIA in the prevention and treatment of myocardial ischemia injury.
Authors:
Wei Xu; Jun Yang; Li-Mao Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Die Pharmazie     Volume:  64     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-17     Completed Date:  2009-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  332-6     Citation Subset:  IM    
Affiliation:
Institute of Chinese Herb Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism
Cardiotonic Agents / pharmacology*
Heart / drug effects
Hemodynamics / drug effects
Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis
Immunohistochemistry
Male
Myocardial Infarction / drug therapy*,  pathology
Myocardium / pathology
Phenanthrenes / pharmacology*
RNA, Messenger / biosynthesis
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Thiobarbituric Acid Reactive Substances / metabolism
Vascular Endothelial Growth Factor A / biosynthesis
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Cardiotonic Agents; 0/Hif1a protein, rat; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Phenanthrenes; 0/RNA, Messenger; 0/Thiobarbituric Acid Reactive Substances; 0/Vascular Endothelial Growth Factor A; 568-73-0/tanshinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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