| Cardioprotective effects of selenium on chromium (VI)-induced toxicity in female rats. | |
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MedLine Citation:
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PMID: 20580087 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Acute exposure to hexavalent chromium compounds can cause cardiotoxicity. Our study pertains to the protective effect of selenium against K(2)Cr(2)O(7)-induced cardiotoxicity. Female Wistar rats were divided into four groups of six each: group I served as controls which received standard diet; group II received in drinking water K(2)Cr(2)O(7) alone (700ppm); group III received both K(2)Cr(2)O(7) and Se (0.5 Na(2)SeO(3)mg/kg of diet); group IV received Se (0.5mg/kg of diet) for 3 weeks. The exposure of rats to chromium promoted oxidative stress with an increase in malondialdehyde levels and a decrease in antioxidant non-enzymatic levels such as glutathione, non-protein thiol and vitamin C, while, an increase in glutathione peroxidase, superoxide dismutase and catalase activities was observed. However, plasma transaminases, lactate dehydrogenase activities, cholesterol, triglycerides and low density lipoprotein-cholesterol levels increased, and high density lipoprotein-cholesterol decreased. Coadministration of Se restored the parameters cited above to near-normal values. The histopathological findings confirmed the biochemical results. |
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Authors:
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Nejla Soudani; Afef Troudi; Hanen Bouaziz; Ibtissem Ben Amara; Tahia Boudawara; Najiba Zeghal |
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Publication Detail:
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Type: Journal Article Date: 2010-06-26 |
Journal Detail:
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Title: Ecotoxicology and environmental safety Volume: 74 ISSN: 1090-2414 ISO Abbreviation: Ecotoxicol. Environ. Saf. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805381 Medline TA: Ecotoxicol Environ Saf Country: United States |
Other Details:
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Languages: eng Pagination: 513-20 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Animal Physiology Laboratory, Life Sciences Department, UR/08-73, Sfax Faculty of Sciences, BP1171, 3000 Sfax , Tunisia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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