| Cardioprotective effects of recombinant human extracellular-superoxide dismutase type C in rat isolated heart subjected to ischemia and reperfusion. | |
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MedLine Citation:
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PMID: 1711638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardioprotective effect of recombinant human extracellular-superoxide dismutase type C (rh-EC-SOD C) was studied in isolated perfused rat heart subjected to left coronary artery ligation for 30 or 60 min followed by 30-min reperfusion. A comparison was made with the effects of bovine CuZn-SOD. Reperfusion after 30-min coronary artery ligation was associated with a release of creatine kinase (CK) into the coronary effluent (71 +/- 5.2 IU/30 min), which was markedly reduced (39 +/- 5.5 IU/30 min) in hearts perfused with rh-EC-SOD C (28 mg/L). CuZn-SOD (4 or 20 mg/l) or a lower concentration of rh-EC-SOD C (5.6 mg/l) did not significantly attenuate CK outflow during reperfusion, however. In both vehicle- and SOD-treated hearts, the left ventricular developed pressure (LVDP) and the coronary flow recovered to 80-90% of baseline at the end of the reperfusion period. Increasing the ischemic period from 30 to 60 min caused a much more pronounced cardiac injury measured after 30-min reperfusion. In the hearts that received vehicle, recovery of LVDP (in percentage of baseline values) at the end of reperfusion was 58 +/- 2%, which was increased to 84 +/- 3 and 83 +/- 5% after treatment with rh-EC-SOD C (28 mg/L) and CuZn-SOD (20 mg/L), respectively. The corresponding values for recovery in coronary flow were 54 +/- 3% (vehicle), 69 +/- 4% (rh-EC-SOD C), and 74 +/- 3% (CuZn-SOD).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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P O Sjöquist; L Carlsson; G Jonason; S L Marklund; T Abrahamsson |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 17 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-07-29 Completed Date: 1991-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 678-83 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Hässle Research Laboratories, Mölndal, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Coronary Disease / physiopathology* Coronary Vessels / drug effects, physiology Creatine Kinase / metabolism Heart / drug effects* Heart Rate / drug effects L-Lactate Dehydrogenase / metabolism Male Myocardial Reperfusion Injury / physiopathology* Myocardium / enzymology Rats Rats, Inbred Strains Recombinant Proteins / pharmacology Superoxide Dismutase / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.15.1.1/Superoxide Dismutase; EC 2.7.3.2/Creatine Kinase |
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