Document Detail


Cardioprotective effects of recombinant human extracellular-superoxide dismutase type C in rat isolated heart subjected to ischemia and reperfusion.
MedLine Citation:
PMID:  1711638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardioprotective effect of recombinant human extracellular-superoxide dismutase type C (rh-EC-SOD C) was studied in isolated perfused rat heart subjected to left coronary artery ligation for 30 or 60 min followed by 30-min reperfusion. A comparison was made with the effects of bovine CuZn-SOD. Reperfusion after 30-min coronary artery ligation was associated with a release of creatine kinase (CK) into the coronary effluent (71 +/- 5.2 IU/30 min), which was markedly reduced (39 +/- 5.5 IU/30 min) in hearts perfused with rh-EC-SOD C (28 mg/L). CuZn-SOD (4 or 20 mg/l) or a lower concentration of rh-EC-SOD C (5.6 mg/l) did not significantly attenuate CK outflow during reperfusion, however. In both vehicle- and SOD-treated hearts, the left ventricular developed pressure (LVDP) and the coronary flow recovered to 80-90% of baseline at the end of the reperfusion period. Increasing the ischemic period from 30 to 60 min caused a much more pronounced cardiac injury measured after 30-min reperfusion. In the hearts that received vehicle, recovery of LVDP (in percentage of baseline values) at the end of reperfusion was 58 +/- 2%, which was increased to 84 +/- 3 and 83 +/- 5% after treatment with rh-EC-SOD C (28 mg/L) and CuZn-SOD (20 mg/L), respectively. The corresponding values for recovery in coronary flow were 54 +/- 3% (vehicle), 69 +/- 4% (rh-EC-SOD C), and 74 +/- 3% (CuZn-SOD).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P O Sjöquist; L Carlsson; G Jonason; S L Marklund; T Abrahamsson
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  17     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-07-29     Completed Date:  1991-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  678-83     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Hässle Research Laboratories, Mölndal, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Coronary Disease / physiopathology*
Coronary Vessels / drug effects,  physiology
Creatine Kinase / metabolism
Heart / drug effects*
Heart Rate / drug effects
L-Lactate Dehydrogenase / metabolism
Male
Myocardial Reperfusion Injury / physiopathology*
Myocardium / enzymology
Rats
Rats, Inbred Strains
Recombinant Proteins / pharmacology
Superoxide Dismutase / pharmacology*
Chemical
Reg. No./Substance:
0/Recombinant Proteins; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.15.1.1/Superoxide Dismutase; EC 2.7.3.2/Creatine Kinase

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