Document Detail

Cardioprotective effects of luteolin during ischemia-reperfusion injury in rats.
MedLine Citation:
PMID:  21178298     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Antioxidants effectively reduce ischemia-reperfusion (IR) injury. The cardioprotective effects of luteolin, a flavonoid that exhibits antioxidant properties and is widely available in many fruits and vegetables, were examined in rats subjected to myocardial IR injury.
METHODS AND RESULTS: Rats were subjected to myocardial ischemia or reperfusion injury to evaluate the antiarrhythmic effects of luteolin. Myocardial infarct size was determined histochemically with triphenyltetrazolium chloride staining of the left ventricle. Luteolin was administered intravenously 15min before occlusion of the coronary artery. The incidence and duration of ventricular tachycardia and ventricular fibrillation and mortality during myocardial ischemia were significantly reduced by luteolin (10µg/kg). Similarly, luteolin (1µg/kg) reduced ventricular arrhythmias and mortality during the reperfusion phase. Pretreatment with luteolin decreased plasma lactate dehydrogenase and nitric oxide (NO) levels. Luteolin (10µg/kg) significantly reduced the myocardial infarct size, as well as malondialdehyde production in tissue samples of myocardial IR injury. Luteolin also downregulated inducible NO synthase protein and mRNA expression, but did not significantly alter neuronal NO synthase or endothelial NO synthase expression.
CONCLUSIONS: Luteolin is capable of protecting the myocardium against IR injury. The actions of luteolin are at least partly mediated through downregulation of NO production and its own antioxidant properties.
Pei-Hu Liao; Li-Man Hung; Yi-Hung Chen; Yu-Hsiang Kuan; Friedrich Bo-Yuan Zhang; Ruey-Hseng Lin; Hung-Che Shih; Shen-Kou Tsai; Shiang-Suo Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-18
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-05-23     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  443-50     Citation Subset:  IM    
Department of Pharmacology and Institute of Medicine, Chung Shan Medical University, Chung Shan Medical University Hospital, Taichung, Taiwan.
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MeSH Terms
Anti-Arrhythmia Agents / pharmacology,  therapeutic use*
Antioxidants / pharmacology,  therapeutic use
Cardiotonic Agents / pharmacology,  therapeutic use*
Drug Evaluation, Preclinical
Gene Expression Regulation, Enzymologic / drug effects
Hemodynamics / drug effects
Isoenzymes / biosynthesis,  genetics
L-Lactate Dehydrogenase / blood
Luteolin / pharmacology,  therapeutic use*
Myocardial Infarction / blood,  complications,  pathology
Myocardial Reperfusion Injury / blood,  drug therapy*
Myocardium / enzymology
Nitric Oxide / blood
Nitric Oxide Synthase / biosynthesis,  genetics
RNA, Messenger / biosynthesis,  genetics
Rats, Sprague-Dawley
Tachycardia, Ventricular / etiology,  prevention & control
Ventricular Fibrillation / etiology,  prevention & control
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Antioxidants; 0/Cardiotonic Agents; 0/Isoenzymes; 0/RNA, Messenger; 10102-43-9/Nitric Oxide; 491-70-3/Luteolin; EC Dehydrogenase; EC Oxide Synthase

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