Document Detail

Cardioprotective effects of lidoflazine in extensive aorta-coronary bypass grafting.
MedLine Citation:
PMID:  6601746     Owner:  NLM     Status:  MEDLINE    
The cardioprotective effects of lidoflazine, a calcium entry blocker, were tested in patients undergoing multiple aorta-coronary bypass grafting (at least four grafts). Intermittent aortic cross-clamping at 25 degrees to 28 degrees C was used. Mean cross-clamp time was 11 minutes for one distal anastomosis. Patients were randomized into three groups: a control group (I), a group (II) pretreated with 0.5 mg . kg-1 lidoflazine intravenously before cardiopulmonary bypass (CPB), and a group (III) pretreated with 1 mg . kg-1 lidoflazine intravenously. The following markers of ischemia are used: (1) adenosine triphosphate (ATP), creatine phosphate (CP) and glycogen determined in transmural left ventricular biopsy specimens taken at the beginning and end of CPB; (2) ultrastructure in a similar pair of specimens; and (3) hemodynamic recovery 15 minutes after cessation of CPB. At the end of the intervention, ATP decreased to 73% in Group I but remained unchanged in Groups II (98%) and III (88%). CP decreased to 82% in Group I and remained unaltered in Groups II (100%) and III (110%). Glycogen decreased in Group I (to 44%) and in Group II (78%) but remained unchanged in Group II (138%). Ultrastructural study showed better preservation of the glycocalyx and sarcolemma in Group III than in Group I. Left ventricular stroke work index remained unaltered after CPB in Group III but decreased in Groups I and II to about 60% of its initial value. Thus lidoflazine pretreatment protects the myocardium in a dose-dependent manner against deterioration of myocardial function and structure.
W Flameng; M Borgers; G J Van der Vusse; R Demeyere; E Vandermeersch; F Thoné; R Suy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  85     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  758-68     Citation Subset:  AIM; IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Cardiopulmonary Bypass
Coronary Artery Bypass*
Glycogen / metabolism
Hemodynamics / drug effects
Hypothermia, Induced
Lidoflazine / therapeutic use*
Middle Aged
Myocardium / metabolism,  ultrastructure
Phosphocreatine / metabolism
Piperazines / therapeutic use*
Reg. No./Substance:
0/Piperazines; 3416-26-0/Lidoflazine; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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