Document Detail


Cardioprotective effects of intracoronary adenosine in diabetic patients undergoing elective percutaneous coronary intervention.
MedLine Citation:
PMID:  24699551     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: Myocardial injury commonly occurs during percutaneous coronary intervention (PCI). Several agents that mimic ischemic preconditioning could help minimize this phenomenon. This study evaluated the cardioprotective role of intracoronary Adenosine in elective PCI.
METHODS: 100 diabetic patients with chronic stable angina were prospectively enrolled, then randomly assigned to undergo PCI with intracoronary Adenosine; 100 μg/stented vessel (group-A,50patients) or standard PCI (group-B,50patients). Cardiac Troponin I (cTnI) & Creatine KinaseMB (CKMB) levels were measured before & 6, 12 and 24 hours postPCI.
RESULTS: Mean age of the study cohort was 57 ± 8 years (males=63%). cTnI level was significantly lower in group-A (6 hours: 7.5 ± 0.2 vs. 15.5 ± 0.5 pg/mL,12 hours: 13.7 ± 0.7 vs. 25.5 ± 0.6 pg/mL and 24 hours: 7.6 ± 0.5 vs. 16 ± 0.3 pg/mL, P< 0.001). After 3 months, the same group showed significantly higher left ventricle ejection fraction (LVEF %) i.e. 64.5 ± 5.7 vs. 56.5 ± 5.3 (P<0.05). There was no statistically significant difference between both groups of patients regarding incidence of major adverse cardiac events (MACE).
CONCLUSION: In diabetic patients undergoing elective PCI, intracoronary Adenosine was associated with decreased incidence of PCI-related myocardial injury & improvement of LVEF% after 3 months.
Authors:
M Shehata
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-3
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  -     ISSN:  1827-1618     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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