| Cardioprotective effects of erythropoietin on postresuscitation myocardial dysfunction in appropriate therapeutic windows. | |
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MedLine Citation:
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PMID: 20449912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Erythropoietin has been noted for its cardioprotective effects. The objective of the study is to investigate its effects on postresuscitation myocardial dysfunction and therapeutic windows. DESIGN: Randomized animal study. SETTING: Animal research laboratory. SUBJECTS: Adult male adult Wistar rats. INTERVENTIONS: Cardiopulmonary resuscitation was started after 6.5 or 9.5 mins of asphyxia-induced cardiac arrest. The resuscitated animals received either erythropoietin (1000, 3000, or 5000 U/kg) or placebo intravenously 3 mins after return of spontaneous circulation. MEASUREMENTS AND MAIN RESULTS: Erythropoietin treatment improved the 3-day survival and left ventricular dP/dt40 and peak negative dP/dt after 6.5 mins asphyxia-induced cardiac arrest. The cardioprotective effects of erythropoietin decreased after 9.5 mins asphyxia-induced cardiac arrest with worse postresuscitation left ventricular dP/dt40 and peak negative dP/dt (p < .01 for both). The erythropoietin showed a dose-dependent response for its cardioprotective effects. The 3-day survival rates were higher in the group treated with erythropoietin 5000 U/kg than with 3000 and 1000 U/kg groups (p = .045 and .003, respectively). Postresuscitation left ventricular dP/dt40 and peak negative dP/dt were more preserved in the group treated with erythropoietin 5000 U/kg than the groups with lower doses (p < .05 for both). CONCLUSIONS: Erythropoietin has the potential to improve postresuscitation myocardial dysfunction and short-term survival in appropriate therapeutic windows. |
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Authors:
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Chien-Hua Huang; Chiung-Yuan Hsu; Min-Shan Tsai; Tzung-Dau Wang; Wei-Tien Chang; Wen-Jone Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Critical care medicine Volume: 36 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: S467-73 Citation Subset: AIM; IM |
Affiliation:
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Department of Emergency Medicine, National Taiwan University Hospital Yun-Lin Branch, Taiwan, ROC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiotonic Agents / administration & dosage, therapeutic use* Coronary Circulation / drug effects Dose-Response Relationship, Drug Erythropoietin / administration & dosage, therapeutic use* Heart Arrest / complications, drug therapy*, physiopathology Hemodynamics / drug effects Male Myocardial Reperfusion Injury / etiology, physiopathology, prevention & control* Random Allocation Rats Rats, Wistar Respiration, Artificial Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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