Document Detail

Cardioprotective effects of dihydrolipoic acid and tocopherol in right heart hypertrophy during oxidative stress.
MedLine Citation:
PMID:  9522025     Owner:  NLM     Status:  MEDLINE    
Rat hearts hypertrophied by exposure of the animals to low oxygen pressure were perfused by the Langendorff technique. After oxidative stress induced by hypoxia/reoxygenation, functional recovery of the hypertrophied right heart was insufficient when compared to non-hypertrophied controls. Accordingly, mitochondrial membrane potential did not recover sufficiently. There was a positive trend for improvement of the rate-pressure product during reoxygenation in lipoic acid (CAS 1077-28-7; 0.8 mumol/l) treated hearts which was also verified for membrane potential. Adenosine 5'-triphosphate and creatine phosphate contents as well as the ATP/ADP ratio in hypertrophied right ventricle were significantly increased after reoxygenation in hearts treated with lipoic acid. With lipoic acid, there was a significantly higher content of glutathione (oxidized form) after reoxygenation, Ca2+ uptake was significantly increased in mitochondria isolated from hypertrophied right ventricles and treated by 12 nmol/mg protein of lipoic acid. The results reveal a distinct improvement of mitochondrial structure/function by lipoic acid and suggest for therapy a combination with the synergistic free radical scavenging properties of tocopherol (CAS 10191-41-0).
T Thürich; J Bereiter-Hahn; M Schneider; G Zimmer
Related Documents :
11731335 - Studies on the transport of acetyl groups from peroxisomes to mitochondria in isolated ...
2868085 - Pseudo-zellweger syndrome: deficiencies in several peroxisomal oxidative activities.
2002205 - Carnitine, valproate, and toxicity.
15083595 - Targets for modulation of fatty acid oxidation in the heart.
4587605 - Transport systems for l-methionine in escherichia coli.
10347055 - Cis/trans isomerase of unsaturated fatty acids of pseudomonas putida p8: evidence for a...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  48     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-27     Completed Date:  1998-04-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  IM    
Gustav-Embden-Zentrum der Biologischen Chemie, Arbeitsgruppe Membranstruktur.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphate / metabolism
Antioxidants / therapeutic use*
Calcium / metabolism
Cardiomegaly / pathology,  physiopathology,  prevention & control*
Coronary Circulation / physiology
Creatine Kinase / metabolism
Free Radical Scavengers / therapeutic use*
Glutathione / metabolism
Heart Function Tests
Membrane Potentials / drug effects,  physiology
Mitochondria, Heart / metabolism
Mitochondrial Swelling / drug effects
Oxidative Stress / physiology*
Rats, Wistar
Thioctic Acid / analogs & derivatives*,  therapeutic use
Vitamin E / therapeutic use*
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 1406-18-4/Vitamin E; 462-20-4/dihydrolipoic acid; 56-65-5/Adenosine Triphosphate; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; 7440-70-2/Calcium; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The relative bioavailability and pharmacokinetics of chloral hydrate and its metabolites
Next Document:  Vasorelaxant and negative inotropic effects of gallopamil and LU49700, a metabolite of gallopamil, o...