| Cardioprotective effects of dihydrolipoic acid and tocopherol in right heart hypertrophy during oxidative stress. | |
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MedLine Citation:
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PMID: 9522025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat hearts hypertrophied by exposure of the animals to low oxygen pressure were perfused by the Langendorff technique. After oxidative stress induced by hypoxia/reoxygenation, functional recovery of the hypertrophied right heart was insufficient when compared to non-hypertrophied controls. Accordingly, mitochondrial membrane potential did not recover sufficiently. There was a positive trend for improvement of the rate-pressure product during reoxygenation in lipoic acid (CAS 1077-28-7; 0.8 mumol/l) treated hearts which was also verified for membrane potential. Adenosine 5'-triphosphate and creatine phosphate contents as well as the ATP/ADP ratio in hypertrophied right ventricle were significantly increased after reoxygenation in hearts treated with lipoic acid. With lipoic acid, there was a significantly higher content of glutathione (oxidized form) after reoxygenation, Ca2+ uptake was significantly increased in mitochondria isolated from hypertrophied right ventricles and treated by 12 nmol/mg protein of lipoic acid. The results reveal a distinct improvement of mitochondrial structure/function by lipoic acid and suggest for therapy a combination with the synergistic free radical scavenging properties of tocopherol (CAS 10191-41-0). |
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Authors:
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T Thürich; J Bereiter-Hahn; M Schneider; G Zimmer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 48 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-04-27 Completed Date: 1998-04-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY |
Other Details:
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Languages: eng Pagination: 13-21 Citation Subset: IM |
Affiliation:
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Gustav-Embden-Zentrum der Biologischen Chemie, Arbeitsgruppe Membranstruktur. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Antioxidants / therapeutic use* Calcium / metabolism Cardiomegaly / pathology, physiopathology, prevention & control* Coronary Circulation / physiology Creatine Kinase / metabolism Free Radical Scavengers / therapeutic use* Glutathione / metabolism Heart Function Tests Male Membrane Potentials / drug effects, physiology Mitochondria, Heart / metabolism Mitochondrial Swelling / drug effects Oxidative Stress / physiology* Perfusion Rats Rats, Wistar Thioctic Acid / analogs & derivatives*, therapeutic use Vitamin E / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radical Scavengers; 1406-18-4/Vitamin E; 462-20-4/dihydrolipoic acid; 56-65-5/Adenosine Triphosphate; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; 7440-70-2/Calcium; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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