Document Detail


Cardioprotective effects of captopril in myocardial ischaemia, ischaemia/reperfusion and infarction.
MedLine Citation:
PMID:  2194813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several experimental studies have suggested that the sulphydryl-containing angiotensin-converting enzyme inhibitor, captopril, has cardioprotective effects in the setting of acute myocardial ischaemia, ischaemia/reperfusion and infarction. We have observed that captopril can reduce the degree of dilatation and early functional myocardial infarct expansion produced by 3 h of permanent coronary artery occlusion in anaesthetized, open-chest dogs. In addition, captopril has been shown to limit experimental infarct size, reduce the incidence of reperfusion arrhythmias, and improve contractile function of stunned myocardium. When administered chronically after myocardial infarction, both experimental and clinical evidence suggests that captopril reduces left ventricular dilatation. Captopril is currently being tested in large clinical trials as adjuvant therapy to thrombolysis.
Authors:
P M Mehta; K Przyklenk; R A Kloner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European heart journal     Volume:  11 Suppl B     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
Affiliation:
Wayne State University, Cardiology Division, Detroit, MI.
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MeSH Terms
Descriptor/Qualifier:
Animals
Captopril / pharmacology*
Coronary Disease / drug therapy*
Humans
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy*
Myocardial Reperfusion Injury / drug therapy*
Chemical
Reg. No./Substance:
62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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