| Cardioprotective effects of Sesbania grandiflora in cigarette smoke-exposed rats. | |
| | |
MedLine Citation:
|
PMID: 18791462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cigarette smoke is a major risk factor of coronary heart disease, myocardial infarction, and cardiac death. It has been reported to contain large amounts of oxidants. This study was undertaken to evaluate the cardioprotective effects of Sesbania grandiflora (S. grandiflora) against cigarette smoke-induced oxidative damage in rats. Adult male Wistar-Kyoto rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with S. grandiflora aqueous suspension (SGAS, 1000 mg/kg body weight per day orally) for a period of 3 weeks. Lactate dehydrogenase activity in serum and cardiac lipid peroxidation product level were significantly increased while the activities of cardiac superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase then the levels of reduced glutathione, vitamin C, and vitamin E were significantly decreased in rats exposed to cigarette smoke. Besides, copper level was elevated, whereas zinc, manganese, and selenium levels were significantly diminished in the heart of rats exposed to cigarette smoke. Treatment with SGAS restored the antioxidant status and retained the levels of micronutrients. These results suggest that chronic cigarette smoke exposure increases the oxidative stress, thereby disquieting the cardiac defense system and S. grandiflora protects the heart from the oxidative damage through its antioxidant potential. |
| | |
Authors:
|
Thiyagarajan Ramesh; Ramalingam Mahesh; Chandrabose Sureka; Vavamohaideen Hazeena Begum |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 52 ISSN: 1533-4023 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-10-21 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 338-43 Citation Subset: IM |
Affiliation:
|
Department of Siddha Medicine, Faculty of Science, Tamil University, Thanjavur-613010, Tamil Nadu, India. thiyagaramesh@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiotonic Agents / chemistry* L-Lactate Dehydrogenase / blood, metabolism Male Phytotherapy* Plant Leaves / chemistry Rats Rats, Inbred WKY Sesbania / chemistry* Smoke / adverse effects* Thiobarbituric Acid Reactive Substances / analysis Tobacco / adverse effects* |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 0/Smoke; 0/Thiobarbituric Acid Reactive Substances; EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant ...
Next Document: Cardioprotection by ouabain and digoxin in perfused rat hearts.