Document Detail

Cardioprotective effect of resvaratrol pretreatment on myocardial ischemia-reperfusion induced injury in rats.
MedLine Citation:
PMID:  16765650     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The major objective of the present study was to examine the cardioprotective effect of resveratrol, an antioxidant presents in red wine, in the rat after ischemia-reperfusion (I/R).
DESIGN: The left coronary artery was in occlusion for 30 min followed by a 120 min reperfusion in anesthetized rats. Animals were pretreated with and without resveratrol before occlusion. The post-ischemic ventricular function (left ventricle maximum systolic pressures and the maximal first derivative of developed pressure) and myocardial infarct size and myocardial nitric oxide (NO) and malonaldehyde (MDA) content were compared.
RESULTS: Resveratrol pretreatment had dramatic cardioprotective effects on post-ischemic ventricular functional recovery and decreasing myocardial infarct size. Resveratrol pretreatment also increased NO and decreased MDA content in myocardium.
CONCLUSIONS: Resveratrol has cardioprotective properties in I/R rats. The cardioprotective effects in the I/R rats may be correlated with its antioxidant activity and upregulation of NO production.
Min Shen; Guo-Liang Jia; Yue-Min Wang; Heng Ma
Publication Detail:
Type:  Journal Article     Date:  2006-06-12
Journal Detail:
Title:  Vascular pharmacology     Volume:  45     ISSN:  1537-1891     ISO Abbreviation:  Vascul. Pharmacol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-09-18     Completed Date:  2007-02-09     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  101130615     Medline TA:  Vascul Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Medical Department of Cardiology, Xijing Hospital, the Fourth Military Medical University, No 15, Chang-Le West Road, xi'an, shaanxi, 710032, China.
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MeSH Terms
Antioxidants / therapeutic use
Cardiotonic Agents / therapeutic use*
Free Radical Scavengers / metabolism
Myocardial Ischemia / drug therapy*
Myocardial Reperfusion Injury / prevention & control*
Nitric Oxide / metabolism
Rats, Sprague-Dawley
Stilbenes / therapeutic use*
Up-Regulation / drug effects
Reg. No./Substance:
0/Antioxidants; 0/Cardiotonic Agents; 0/Free Radical Scavengers; 0/Stilbenes; 10102-43-9/Nitric Oxide; Q369O8926L/resveratrol

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