Document Detail


Cardioprotective effect of mangiferin on isoproterenol induced myocardial infarction in rats.
MedLine Citation:
PMID:  16538859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Isoproterenol (ISPH) induced myocardial infarction was confirmed by disturbances in serum and heart tissue marker enzymes such as lactate dehydrogenase (LDH), creatine phospho kinase (CPK), aspartate transaminase (AST) and alanine transaminase (ALT), increased level of lipid peroxidation and histopathological changes in the heart of ISPH administered rats. Pretreatment with mangiferin (10 mg/100 g body weight) for 28 days was found to ameliorate the effect of ISPH-induced pathological changes, reduced the lipid peroxide formation and retained the myocardial marker enzyme activities at near normal level. The above results indicate the cardioprotective effect of mangiferin against ISPH-induced myocardial infarction in rats.
Authors:
S Prabhu; Mallika Jainu; K E Sabitha; C S Shyamala Devi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  44     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-16     Completed Date:  2006-08-21     Revised Date:  2013-01-28    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Madras, Guindy Campus Chennai 600 025, India.
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / metabolism
Animals
Aspartate Aminotransferases / metabolism
Cardiotonic Agents / pharmacology*
Dose-Response Relationship, Drug
Isoproterenol / pharmacology*
Male
Myocardial Infarction / chemically induced*,  metabolism,  pathology,  prevention & control*
Rats
Rats, Wistar
Xanthones / pharmacology*
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Xanthones; 1M84LD0UMD/mangiferin; 7683-59-2/Isoproterenol; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

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