Document Detail


Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow.
MedLine Citation:
PMID:  21796804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate whether liposomal prostaglandin E1 (lipo-PGE1) can decrease reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction (AMI).
METHODS: Twenty-two male Chinese mini-swines were randomized into three groups: six in a sham-operation group, and eight each in the control and lipo-PGE1 groups. The distal part of the left anterior descending coronary artery (LAD) in the latter two groups was completely occluded for 2 h, and then reperfused for 3 h. Lipo-PGE1 (1 μg/kg) was injected 10 min before LAD occlusion until reperfusion for 1 h in the lipo-PGE1 group. Hemodynamic data and proinflammatory cytokines were examined before AMI, 2 h after occlusion, and 1, 2, and 3 h after reperfusion. Myocardial contrast echocardiography (MCE) and double staining were performed to evaluate the myocardial no-reflow area (NRA).
RESULTS: Left ventricular systolic pressure and end-diastolic pressure significantly improved in the lipo-PGE1 group after reperfusion compared with the control group and also 2 h after AMI (P<0.05 for both). MCE and double staining both showed that lipo-PGE1 decreased reperfusion NRA after AMI (P<0.05, P<0.01). Lipo-PGE1 decreased serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) after myocardial infarction reperfusion (P<0.05 for both).
CONCLUSIONS: Lipo-PGE1 is cardioprotective in our porcine model of myocardial infarction reperfusion no-reflow, decreasing NRA and attenuating the inflammatory response.
Authors:
Jia-Hui Li; Peng Yang; Ai-Li Li; Yong Wang; Yuan-Nan Ke; Xian-Lun Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  12     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-28     Completed Date:  2011-12-13     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  638-43     Citation Subset:  IM    
Affiliation:
Department of Cardiology, China-Japan Friendship Hospital, Beijing 100029, China.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Alprostadil / metabolism*
Animals
Coronary Vessels / pathology
Disease Models, Animal
Echocardiography / methods
Interleukin-6 / metabolism
Liposomes / metabolism*
Male
Myocardial Infarction / metabolism*
Myocardial Reperfusion
Myocardium / metabolism
Radioimmunoassay / methods
Random Allocation
Swine
Swine, Miniature
Time Factors
Tumor Necrosis Factor-alpha / metabolism
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/Liposomes; 0/Tumor Necrosis Factor-alpha; 745-65-3/Alprostadil
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