Document Detail

Cardioprotective actions of garlic (Allium sativum).
MedLine Citation:
PMID:  8457243     Owner:  NLM     Status:  MEDLINE    
The influence of an intake of garlic powder (1%--corresponding to Kwai/Sapec--added to a standard chow for a 10-week period) on the susceptibility to ventricular arrhythmias under ischemia and reperfusion was investigated in the isolated rat heart (Langendorff preparation) perfused with a modified Krebs-Henseleit solution. The incidence of ventricular tachycardia (VT) and fibrillation (VF) after ligation of the descending branch of the left coronary artery (LAD) (20 min) was significantly reduced in the garlic group as compared to untreated controls (VT: 0% vs. 35.5%; VF: 50% vs. 88%). The size of the ischemic zone was significantly smaller (31.7% vs. 40.9% of total heart tissue). The reperfusion experiments (5 min after 10 min ischemia) revealed similar results (VT: 50% vs. 100%; VF: 30% vs. 90%). The time until occurrence of extrasystoles and VT or VF was prolonged in most cases, and the duration of arrhythmias was abbreviated. No significant alterations in cardiac membrane fatty acid composition could be found. Inhibition of cyclooxygenase by acetylsalicylic acid (ASA) caused a moderate increase in arrhythmias and ischemic zone in the garlic group as well as in untreated controls under the conditions of the present experiments. Thus, it seems that the prostaglandin system does not play a predominant role in the cardioprotective action of garlic. The significance of free radical scavenging activity of garlic for its antiarrhythmic effects has to be established.
H Isensee; B Rietz; R Jacob
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  43     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-22     Completed Date:  1993-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  94-8     Citation Subset:  IM    
Institute of Physiology II, University of Tübingen, Fed. Rep. of Germany.
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MeSH Terms
Arrhythmias, Cardiac / prevention & control*
Aspirin / pharmacology
Cyclooxygenase Inhibitors / pharmacology
Electrocardiography / drug effects
Epoprostenol / physiology
Fatty Acids / metabolism
Heart / drug effects*
Membranes / drug effects,  metabolism
Myocardial Ischemia / pathology,  prevention & control*
Myocardial Reperfusion Injury / prevention & control
Myocardium / metabolism,  pathology
Plants, Medicinal*
Rats, Wistar
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Fatty Acids; 35121-78-9/Epoprostenol; 50-78-2/Aspirin

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