Document Detail


Cardioprotective effect of mangiferin on left ventricular remodeling in rats.
MedLine Citation:
PMID:  22759807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to clarify the protective role of mangiferin on postinfarction myocardial remodeling and potential mechanisms. The myocardial infarction (MI) model was established by ligating the left anterior descending coronary artery. Cardiac function, myocardial apoptosis and fibrosis, serum tumor necrosis factor-α (TNF-α) and phosphorylated p38 mitogen-activated protein kinase (MAPK) were examined by echocardiography, histological staining, ELISA and Western blot, respectively. Mangiferin attenuated MI and prevented the development of intercellular fibrosis. Western blotting underscores that the p38 MAPK cascade plays an important role in the cardioprotective effect of mangiferin during MI. Inhibition of p38 MAPK significantly decreased serum TNF-α levels. Transferase-mediated uridine nick end labeling and Masson staining also showed that mangiferin reduced apoptosis and fibrosis in myocardium remodeling. Based on these results, we conclude that mangiferin has a therapeutic effect on post-MI left ventricular remodeling and improves cardiac function.
Authors:
Dezhi Zheng; Jun Hou; Yingbin Xiao; Zhe Zhao; Lin Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-29
Journal Detail:
Title:  Pharmacology     Volume:  90     ISSN:  1423-0313     ISO Abbreviation:  Pharmacology     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-02     Completed Date:  2012-12-27     Revised Date:  2013-01-28    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  78-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Blood Pressure / drug effects
Cardiotonic Agents / therapeutic use*
Caspase 3 / metabolism
Drugs, Chinese Herbal / therapeutic use
Fibrosis
Male
Myocardial Infarction / drug therapy*,  pathology,  physiopathology
Myocardium / pathology,  ultrastructure
Proto-Oncogene Proteins c-bcl-2 / metabolism
Rats
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha / blood
Ventricular Remodeling / drug effects*,  physiology
Xanthones / therapeutic use*
p38 Mitogen-Activated Protein Kinases / physiology
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Drugs, Chinese Herbal; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Necrosis Factor-alpha; 0/Xanthones; 1M84LD0UMD/mangiferin; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 3.4.22.-/Caspase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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